Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3565
Abstract: Several reports indicate that diabetes determines an increased mortality risk in patients with coronavirus disease 19 (COVID‐19) and a good glycaemic control appears to be associated with more favourable outcomes. Evidence also supports that COVID‐19… read more here.
Keywords: dysfunction; vascular dysfunction; synergistic combination; inflammation vascular ... See more keywords
Favorable effect of rivaroxaban against vascular dysfunction in diabetic mice by inhibiting NLRP3 inflammasome activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30807
Abstract: Cardiovascular disease (CVD) is the leading cause of death in various complications of type 2 diabetes mellitus (T2DM). Rivaroxaban (Xarelto; Bayer), an oral direct factor Xa (FXa) inhibitor, prevents the activation of the coagulation cascade… read more here.
Keywords: vascular dysfunction; dysfunction; mice; rivaroxaban ... See more keywords
Postoperative association between impaired renal function and vascular dysfunction in liver transplant recipients
Sign Up to like & getrecommendations! Published in 2022 at "Liver Transplantation"
DOI: 10.1002/lt.26572
Abstract: To the editor, Liver transplantation (LT) recipients have an increased risk of developing cardiovascular disease (CVD), but the physiological mechanisms driving this risk are not yet fully understood. A decline in renal function after transplant… read more here.
Keywords: vascular dysfunction; dysfunction; risk; renal function ... See more keywords
Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_30
Abstract: Vascular inflammation in cardiovascular diseases is recognized to be linked with immune cell activation. Recruitment of immune cells into the vessel wall is an early step in angiotensin II-induced vascular dysfunction and arterial hypertension. Exploring… read more here.
Keywords: angiotensin induced; inflammation; assessment vascular; vascular dysfunction ... See more keywords
Involvement of inducible nitric oxide synthase and estrogen receptor ESR2 (ER&bgr;) in the vascular dysfunction in female type 1 diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.11.030
Abstract: Aims: Inflammation is involved in diabetes‐related vascular dysfunction. Estrogen receptor ESR2/ER&bgr; induces the expression of inducible nitric oxide (NO) synthase (iNOS) and inflammation. The present study investigated the effect of alloxan‐induced type 1 diabetes on… read more here.
Keywords: esr2; female; expression; vascular dysfunction ... See more keywords
Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.009
Abstract: BACKGROUND Hypertension-induced microvascular brain injury is a major vascular contributor to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the hyperphosphorylation of tau and cell death in an accelerated spontaneously hypertensive stroke prone… read more here.
Keywords: dorsolateral cortex; hyperphosphorylation; vascular dysfunction; hypoxia promotes ... See more keywords
Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101271
Abstract: Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular response to oxidative stress. We evaluated the impact… read more here.
Keywords: pharmacological activation; dysfunction; activation nrf2; vascular dysfunction ... See more keywords
Systemic vascular dysfunction is associated with emphysema burden in mild COPD.
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory medicine"
DOI: 10.1016/j.rmed.2018.01.007
Abstract: BACKGROUND Cardiovascular diseases play a major role in morbidity and mortality in the earlier stages of COPD. We hypothesized that systemic vascular dysfunction would be present even in patients who are currently considered at "low-risk"… read more here.
Keywords: flow mediated; systemic vascular; emphysema burden; vascular dysfunction ... See more keywords
l-arginine alleviates doxorubicin-induced endothelium-dependent dysfunction by promoting nitric oxide generation and inhibiting apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.05.016
Abstract: BACKGROUND/AIMS Patients with doxorubicin (Dox) treatment have a high risk of developing vascular toxicity with an unknown mechanism. l-arginine is a substrate for nitric oxide (NO). The decreased level of arginine-NO metabolite in Dox-treated cancer… read more here.
Keywords: dox induced; apoptosis; dysfunction; generation ... See more keywords
Identification of aberrantly expressed circular RNAs in hyperlipidemia-induced retinal vascular dysfunction in mice.
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DOI: 10.1016/j.ygeno.2020.09.055
Abstract: Hyperlipidemia-induced retinal vascular dysfunction is a complex pathological process. circRNAs are important regulators of biological processes and disease progression. However, the expression pattern of circRNAs in hyperlipidemia-induced retinal vascular dysfunction remains unclear. Herein, we used… read more here.
Keywords: retinal vascular; ontology; induced retinal; hyperlipidemia ... See more keywords
Alteration of purinergic signaling in diabetes: Focus on vascular function.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.02.004
Abstract: Diabetes is an important risk factor for the development of cardiovascular disease including atherosclerosis and ischemic heart disease. Vascular complications including macro- and micro-vascular dysfunction are the leading causes of morbidity and mortality in diabetes.… read more here.
Keywords: dysfunction; signaling diabetes; alteration purinergic; mediated purinergic ... See more keywords