Defining Nonadherence and Nonpersistence to Anti-Vascular Endothelial Growth Factor Therapies in Neovascular Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2021.1660
Abstract: Importance Poor adherence or persistence to treatment can be a barrier to optimizing clinical practice (real-world) outcomes to intravitreal injection therapy in patients with neovascular age-related macular degeneration (nAMD). Currently, there is a lack of… read more here.
Keywords: vascular endothelial; nonadherence nonpersistence; treatment; anti vascular ... See more keywords
Toxic effects of dimethyl sulfoxide on red blood cells, platelets, and vascular endothelial cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12193
Abstract: Dimethyl sulfoxide (DMSO) is widely used in biological studies as a cryoprotective agent for cells and tissues, and also for cryopreserved platelets (PLTs). However, few data on the toxic effects of DMSO following intravenous infusion… read more here.
Keywords: red blood; vascular endothelial; toxic effects; dimethyl sulfoxide ... See more keywords
Tuning the Local Availability of VEGF within Glycosaminoglycan‐Based Hydrogels to Modulate Vascular Endothelial Cell Morphogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202000068
Abstract: Incorporation of sulfated glycosaminoglycans (GAGs) into cell‐instructive polymer networks is shown to be instrumental in controlling the diffusivity and activity of growth factors. However, a subtle balance between local retention and release of the factors… read more here.
Keywords: sulfation pattern; cell instructive; vascular endothelial; local availability ... See more keywords
New [1,2,4]triazolo[4,3‐c]quinazoline derivatives as vascular endothelial growth factor receptor‐2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200133
Abstract: In continuation of our previous efforts in the field of design and synthesis of vascular endothelial growth factor receptor (VEGFR)‐2 inhibitors, a new series of [1,2,4]triazolo[4,3‐c]quinazoline derivatives were designed and synthesized as modified analogs of… read more here.
Keywords: design synthesis; compound; endothelial growth; factor receptor ... See more keywords
Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1529
Abstract: Radiation‐induced brain injury (RBI) usually occurs six months to three years after irradiation, often shows cognitive dysfunction, epilepsy, and other neurological dysfunction. In severe cases, it can cause a wide range of cerebral edema, even… read more here.
Keywords: vascular endothelial; modulates vascular; ionizing radiation; radiation modulates ... See more keywords
Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2208
Abstract: Tumor angiogenesis plays an important role in disease progression, and RhoC has been previously found to be expressed in vascular endothelial cells (VECs); however, its role in tumor angiogenesis requires clarification. This study aimed to… read more here.
Keywords: angiogenesis; rhoc downregulation; vascular endothelial; endothelial cells ... See more keywords
Early hypertension and neutropenia are predictors of treatment efficacy in metastatic colorectal cancer patients administered FOLFIRI and vascular endothelial growth factor inhibitors as second‐line chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3638
Abstract: Three vascular endothelial growth factor (VEGF) inhibitors, Bevacizumab (BEV), ramucirumab (RAM), and aflibercept (AFL), are widely used for metastatic colorectal cancer (mCRC) patients who are treated with second‐line chemotherapy. The difference in outcome between the… read more here.
Keywords: vascular endothelial; endothelial growth; growth factor; cancer ... See more keywords
Dopamine 1 receptors inhibit apoptosis via activating CSE/H2S pathway in high glucose‐induced vascular endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11794
Abstract: High glucose (HG)‐induced dysfunction of vascular endothelial cells plays a crucial role in the development of diabetic vascular complications. Inhibition of cystathionine γ‐synthase/hydrogen sulfide (CSE/H2S) pathway is one of the causes of vascular endothelial cell… read more here.
Keywords: h2s pathway; effect; endothelial cells; cse h2s ... See more keywords
Vascular endothelial growth factor and programmed death‐1 pathway inhibitors in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32361
Abstract: Advanced renal cell carcinoma has historically carried a poor prognosis with very limited treatment options. However, in recent years, the treatment landscape has changed drastically, with many new therapeutic options and improved survival for patients.… read more here.
Keywords: renal cell; vascular endothelial; endothelial growth; cell carcinoma ... See more keywords
A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22083
Abstract: Following the pharmacophoric features of vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors, a novel thieno[2,3-d]pyrimidine derivative has been designed and its activity against VEGFR-2 has been demonstrated by molecular docking studies that showed an… read more here.
Keywords: pyrimidine derivative; growth; thieno pyrimidine; drug ... See more keywords
LncRNA HOXA11‐AS promotes vascular endothelial cell injury in atherosclerosis by regulating the miR‐515‐5p/ROCK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13815
Abstract: Long non‐coding RNA HOXA11‐AS participated in heart disease. In this study, we aim to evaluate the potential roles of HOXA11‐AS in atherosclerosis and its underlying mechanisms. read more here.
Keywords: promotes vascular; hoxa11 promotes; lncrna hoxa11; atherosclerosis ... See more keywords