New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27580
Abstract: Vascular leak is a key driver of organ injury in diseases, and strategies that reduce enhanced permeability and vascular inflammation are promising therapeutic targets. Activation of the angiopoietin‐1 (ANG1)‐Tie2 tyrosine kinase signaling pathway is an… read more here.
Keywords: vascular leakage; hepta ang1; new soluble; ang1 ... See more keywords
Evaluating VEGF-Induced Vascular Leakage Using the Miles Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2217-9_21
Abstract: Before the endothelial mitogenic activity of the Vascular Endothelial Growth Factor A (VEGF) was described, VEGF had already been identified for its ability to induce vascular leakage. VEGF-induced vascular leakage has been most frequently studied… read more here.
Keywords: using miles; induced vascular; vegf induced; vascular leakage ... See more keywords
Pro-angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41115-2
Abstract: Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis, but VEGF-induced angiogenesis is often accompanied by a vascular permeability response. Ginsenosides are triterpenoid saponins from the well-known medicinal plant, ginseng, and have been… read more here.
Keywords: pro angiogenic; ginsenosides rh1; vascular leakage; endothelial cells ... See more keywords
Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53627-y
Abstract: Diabetic retinopathy is a major complication of diabetes mellitus and a leading cause of blindness. The pathogenesis of diabetic retinopathy is accompanied by chronic low-grade inflammation. Evidence shows that the blockade of adenosine A2A receptors… read more here.
Keywords: intravitreal injection; vascular leakage; injection; antagonist ... See more keywords
Stabilin-1-Mediated Efferocytosis Protects against Vascular Leakage in Sepsis: A Novel Therapeutic Approach?
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1673688
Abstract: Sepsis is a complex clinical syndrome with high lethality characterized by systemic inflammation and organ failure.1 Although intensive research over the past decades has identified several mechanisms contributing to sepsis pathology, sepsis represents a major… read more here.
Keywords: sepsis; stab; efferocytosis; vascular leakage ... See more keywords
Targeting β1-integrin inhibits vascular leakage in endotoxemia
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1722317115
Abstract: Significance Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. Here, we show that targeting β1-integrin in vivo with inhibitory antibodies or deletion of a single… read more here.
Keywords: leakage; endotoxemia; vascular leakage; targeting integrin ... See more keywords
Evans blue and FITC-dextran double labeling reveals precise sequence of vascular leakage and glial responses after exposure to mild-level blast-associated shock waves.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0155
Abstract: Blast-induced shock waves (BSWs) are responsible for several aspects of psychiatric disorders that are collectively termed mild traumatic brain injury (mTBI). The pathophysiology of mTBI includes vascular leakage resulting from blood-brain barrier (BBB) disruption. In… read more here.
Keywords: evans blue; precise sequence; fitc dextran; vascular leakage ... See more keywords
Fc-saxatilin suppresses hypoxia-induced vascular leakage by regulating endothelial occludin expression.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-06-0469
Abstract: Vascular leakage due to compromised integrity of the endothelial barrier is closely associated with brain damage in several neurological disorders, including ischaemic stroke. Saxatilin, a snake venom disintegrin containing the Arg-Gly-Asp (RGD) motif, exerts thrombolytic… read more here.
Keywords: vascular leakage; expression; hypoxia induced; saxatilin ... See more keywords
von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-03-841932
Abstract: von Willebrand factor (VWF) is an adhesive ligand, and its activity is proteolytically regulated by the metalloprotease ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat 13). An elevated level of plasma VWF has… read more here.
Keywords: microvesicle; vascular leakage; von willebrand; willebrand factor ... See more keywords
Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.240077
Abstract: AIMS Endothelial barrier dysfunction leads to edema and vascular leak, carrying high morbidity and mortality. Previously, Abl kinase inhibition was shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl… read more here.
Keywords: turnover; endothelial barrier; bosutinib; vascular leakage ... See more keywords
In vivo evaluation of a lipopolysaccharide-induced ear vascular leakage model in mice using photoacoustic microscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical optics express"
DOI: 10.1364/boe.471079
Abstract: Sepsis is caused by dysregulated host inflammatory response to infection. During sepsis, early identification and monitoring of vascular leakage are pivotal for improved diagnosis, treatment, and prognosis. However, there is a lack of research on… read more here.
Keywords: microscopy; ear vascular; photoacoustic microscopy; model ... See more keywords