Nitrite treatment downregulates vascular MMP‐2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects
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DOI: 10.1016/j.freeradbiomed.2018.11.002
Abstract: ABSTRACT Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)− 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non‐antihypertensive dose exerts antioxidant effects and attenuates… read more here.
Keywords: remodeling hypertension; vascular mmp; vascular remodeling; hypertension ... See more keywords