The significance and application of vascular niche in the development and maintenance of hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-018-2450-2
Abstract: Deriving hematopoietic stem cells (HSCs) from human pluripotent stem cells is one of major goals in stem cell and hematological research. To induce HSCs from human pluripotent stem cells, many attempts to mimic embryonic development… read more here.
Keywords: vascular niche; maintenance; stem cells; development ... See more keywords
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.11.019
Abstract: Regenerative capacity is frequently impaired in aged organs. Stress to aged organs often causes scar formation (fibrosis) at the expense of regeneration. It remains to be defined how hematopoietic and vascular cells contribute to aging-induced… read more here.
Keywords: fibrosis; regeneration; vascular niche; hematopoietic vascular ... See more keywords
The role of vascular niche and endothelial cells in organogenesis and regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112398
Abstract: The term vascular niche indicate the physical and biochemical microenvironment around blood vessel where endothelial cells, pericytes, and smooth muscle cells organize themselves to form blood vessels and release molecules involved in the recruitment of… read more here.
Keywords: niche endothelial; vascular niche; endothelial cells; role vascular ... See more keywords
Comprehensive Review of the Vascular Niche in Regulating Organ Regeneration and Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells translational medicine"
DOI: 10.1093/stcltm/szac070
Abstract: The vasculature occupies a large area of the body, and none of the physiological activities can be carried out without blood vessels. Blood vessels are not just passive conduits and barriers for delivering blood and… read more here.
Keywords: organ regeneration; regeneration fibrosis; vascular niche;
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abe6805
Abstract: Description A temporal systems biology screen of premetastatic endothelial cells identified LRG1 as a therapeutic target for restricting metastases. A LaRGe effect on metastases A more complete understanding of the vascular niche as it evolves… read more here.
Keywords: lrg1; metastasis; vascular niche; growth ... See more keywords
YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis
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DOI: 10.1158/0008-5472.can-20-0242
Abstract: YAP-dependent changes of the liver vascular niche comprise the formation of heterologous communication hubs in which tumor cell-derived factors modify the cross-talk between EC subpopulations. The oncogene yes-associated protein (YAP) controls liver tumor initiation and… read more here.
Keywords: hgf met; communication; vascular niche; cell ... See more keywords
RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2017009324
Abstract: Although the function of Runt-related (RUNX) transcription factors has been well characterized in leukemogenesis and regarded as an ideal target in antileukemia strategies, the effect of RUNX-inhibition therapy on bone marrow niche cells andr its… read more here.
Keywords: niche; vascular niche; runx transcription; bone marrow ... See more keywords
Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.912060
Abstract: Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in… read more here.
Keywords: regulator hematopoietic; vascular niche; niche; hematopoietic vascular ... See more keywords
Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury
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DOI: 10.7150/thno.64963
Abstract: Background: Irradiation disrupts the vascular niche where hematopoietic stem cells (HSCs) reside, causing delayed hematopoietic reconstruction. The subsequent recovery of sinusoidal vessels is key to vascular niche regeneration and a prerequisite for hematopoietic reconstruction. We… read more here.
Keywords: regeneration; vascular niche; niche; irradiation injury ... See more keywords
Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche
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DOI: 10.7150/thno.67710
Abstract: The endoplasmic reticulum unfolded protein response (UPR) is a conserved adaptive signaling in ER homeostasis and has emerged as critical in highly proliferating cells and potential treatment target for acute T-cell lymphoblastic leukemia (T-ALL). Methods:… read more here.
Keywords: jag1; vascular niche; perk; bone marrow ... See more keywords