Low‐ dose Apatinib promotes vascular normalization and hypoxia reduction and sensitizes radiotherapy in lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5113
Abstract: Abnormal vascular network of tumor can create a hypoxic microenvironment, and reduce radiotherapy sensitivity. Normalization of tumor vasculature can be a new therapeutic strategy for sensitizing radiotherapy. This study aimed to explore the effect of… read more here.
Keywords: vascular normalization; lung cancer; radiotherapy; normalization ... See more keywords
Vascular Normalization Was Associated with Colorectal Tumor Regression upon Anti-PD-L1 Combinational Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/5867047
Abstract: Anti-PD-L1 therapy exhibits durable efficacy, but only in a small fraction of cancer patients. The immunosuppressive tumor microenvironment (TME) is a crucial obstacle that impedes cancer immunotherapy. Here, we found that anti-PD-L1 therapy coupled with… read more here.
Keywords: vascular normalization; tumor regression; therapy; colorectal tumor ... See more keywords
JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL8.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.161675
Abstract: Tumor vascular normalization prevents tumor cells from breaking through the basement membrane and entering the vasculature, and then inhibiting metastasis initiation. In this study, we reported that the anti-tumor peptide JP1 regulates the mitochondria metabolic… read more here.
Keywords: metastasis; vascular normalization; jp1; vasculature ... See more keywords
Tumor vascular normalization monitor by non-contrast intravoxel incoherent motion diffusion-weighted MRI.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15707
Abstract: e15707Background: Tumor vascular normalization has been proposed as a new concept for anti-tumor angiogenesis, and the normalization time window had been considered as an opportunity to improve dru... read more here.
Keywords: monitor non; normalization monitor; tumor vascular; vascular normalization ... See more keywords
MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment
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DOI: 10.18632/oncotarget.22600
Abstract: The beginning and the end of the vascular normalization window are not clear in response to anti-angiogenic therapies. We used dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion MRI (IVIM-MRI) to noninvasively evaluate the vascular… read more here.
Keywords: anti vessel; treatment; normalization window; vascular normalization ... See more keywords
Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s187750
Abstract: Purpose Large-scale studies have revealed that appropriate antiangiogenic treatment enables the recovery of the normal structure and function of solid tumor vessels. Epigallocatechin-3-gallate (EGCG), a natural extract of green tea, has multiple effects on angiogenesis.… read more here.
Keywords: egcg; tumor; cell; vascular normalization ... See more keywords
Traditional Chinese Medicine (TCM) Astragalus Membranaceus and Curcuma Wenyujin Promote Vascular Normalization in Tumor-derived Endothelial Cells of Human Hepatocellular Carcinoma
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DOI: 10.21873/anticanres.13400
Abstract: Background/Aim: The aim of the present study was to investigate the vascular normalization effect of traditional Chinese medicine Astragalus membranaceus (AM) and Curcuma wenyujin (CW) on tumor-derived endothelial cells (TECs). Materials and Methods: TECs were… read more here.
Keywords: medicine; tumor derived; vascular normalization; expression ... See more keywords
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8996
Abstract: Anti-angiogenic therapy provides transient tumor vascular normalization, which results in a window of opportunity for improvement of radio- or chemotherapy. Biomarkers indicating this window are required for rationalizing anti-angiogenesis. Anterior gradient 2 (AGR2), the majority… read more here.
Keywords: treatment; vessel; vascular normalization; normalization ... See more keywords