Propranolol increases vascular permeability through pericyte apoptosis and exacerbates oxygen-induced retinopathy.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.041
Abstract: Retinopathy of prematurity (ROP) is an eye disease that causes blindness due to delayed vascular growth, retinal ischemia, and resulting abnormal angiogenesis. Nonselective β-antagonist propranolol is in clinical trials for the treatment of ROP due… read more here.
Keywords: rop; permeability; propranolol; pericyte apoptosis ... See more keywords
Exploiting passive nanomedicine accumulation at sites of enhanced vascular permeability for non‐cancerous applications
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.06.013
Abstract: Abstract Over the past few decades, enhanced permeability of tumor vasculature was actively exploited for targeted delivery of anticancer nanomedicines resulting in numerous pharmaceutical products. Formation of new immature and leaky vessels along with inflammatory… read more here.
Keywords: accumulation; exploiting passive; enhanced vascular; permeability ... See more keywords
Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2018.10.021
Abstract: Rift Valley fever virus (RVFV) is a zoonotic disease of livestock that causes several clinical outcomes in people including febrile disease, hemorrhagic fever, and/or encephalitis. After aerosol infection with RVFV, Lewis rats develop lethal encephalitic… read more here.
Keywords: fever; permeability brain; brain; virus ... See more keywords
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis
Sign Up to like & getrecommendations! Published in 2017 at "Bone Marrow Transplantation"
DOI: 10.1038/bmt.2016.241
Abstract: Recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage and alleviated edema in individuals with sinusoidal obstruction syndrome and engraftment syndrome after hematopoietic stem cell transplantation. We previously showed that rTM increased levels of antiapoptotic protein… read more here.
Keywords: src cadherin; cadherin; vascular permeability; calcineurin inhibitor ... See more keywords
Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213317120
Abstract: Significance Due to increased exposure to various infectious diseases, including COVID-19, there is an urgent need for novel drugs that reduce mortality from severe infectious diseases. Although current drugs can suppress pathogen reproduction, immune cell… read more here.
Keywords: infectious diseases; permeability mortality; severe infectious; mortality ... See more keywords
Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a rat model
Sign Up to like & getrecommendations! Published in 2021 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2021.2011198
Abstract: Abstract Aims Ginkgo biloba extract (EGb) has been widely applied in the treatment of cerebrovascular and neurological diseases. However, the effect of EGb761 on ovarian hyperstimulation syndrome (OHSS), a vascular disorder and life-threatening complication of… read more here.
Keywords: ginkgo biloba; biloba extract; vascular permeability; treatment ... See more keywords
Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a rat model
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2034147
Abstract: Abstract Aims Ginkgo biloba extract (EGb) has been widely applied in the treatment of cerebrovascular and neurological diseases. However, the effect of EGb761 on ovarian hyperstimulation syndrome (OHSS), a vascular disorder and life-threatening complication of… read more here.
Keywords: biloba extract; ginkgo biloba; vascular permeability; model ... See more keywords
HDAC inhibitor, MS-275, increases vascular permeability by suppressing Robo4 expression in endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Tissue Barriers"
DOI: 10.1080/21688370.2021.1911195
Abstract: ABSTRACT Roundabout guidance receptor 4 (Robo4) is an endothelial-specific membrane protein that suppresses pathological angiogenesis and vascular hyperpermeability by stabilizing endothelial cells. Robo4 suppresses severe systemic inflammation induced by pathogens and endotoxins and inhibits tumor… read more here.
Keywords: robo4 expression; expression; endothelial cells; hdac inhibitor ... See more keywords
Spermine oxidase inhibitor, MDL 72527, reduced neovascularization, vascular permeability, and acrolein-conjugated proteins in a mouse model of ischemic retinopathy
Sign Up to like & getrecommendations! Published in 2024 at "Tissue Barriers"
DOI: 10.1080/21688370.2024.2347070
Abstract: ABSTRACT Disruptions in polyamine metabolism have been identified as contributing factors to various central nervous system disorders. Our laboratory has previously highlighted the crucial role of polyamine oxidation in retinal disease models, specifically noting elevated… read more here.
Keywords: spermine oxidase; vascular permeability; neovascularization vascular; mdl 72527 ... See more keywords
Validation of a new vascular graft: vascular permeability and endothelialization
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Surgery"
DOI: 10.1093/bjs/znae322.012
Abstract: Cardiovascular diseases are the leading cause of death globally. Tissue-engineered vascular grafts (TEVGs) are a promising therapeutic option because they can replace or repair the biological functions of blood vessels. Poly(vinylidene fluoride) (PVDF) is a… read more here.
Keywords: permeability; validation new; new vascular; permeability endothelialization ... See more keywords
Distinct Effects of Sevoflurane and Propofol on Vascular Permeability In Vitro and in a Mouse Model
Sign Up to like & getrecommendations! Published in 2025 at "Anesthesiology"
DOI: 10.1097/aln.0000000000005434
Abstract: Background: General anesthetics may substantially influence endothelium function, potentially affecting outcomes of surgical patients, but their effects are unclear. Here, the authors studied a commonly used inhaled anesthetic, sevoflurane, and an intravenous anesthetic, propofol, on… read more here.
Keywords: sevoflurane propofol; permeability; mouse model; vitro ... See more keywords