HDACs regulate the differentiation of endothelial cells from human iPSCs
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DOI: 10.1002/cbf.3729
Abstract: Human induced pluripotent stem cells (hiPSCs) possess the potential to differentiate toward vascular cells including endothelial cells (ECs), pericytes, and smooth muscle cells. Epigenetic mechanisms including DNA methylation and histone modification play a crucial role… read more here.
Keywords: vascular progenitors; hdacs; endothelial cells; expression ... See more keywords
Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30626-z
Abstract: Severe vascular calcification develops almost invariably in chronic kidney patients posing a substantial risk to quality of life and survival. This unmet medical need demands identification of novel therapeutic modalities. We aimed to pinpoint components… read more here.
Keywords: proinflammatory cytokines; vascular progenitors; phenotype conversion; conversion vascular ... See more keywords