Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c180026
Abstract: Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of molecular and cellular physiological responses leading to… read more here.
Keywords: growth remodeling; ischemic vascular; vascular growth; vascular remodeling ... See more keywords
Mouse Model of Wire Injury-Induced Vascular Remodeling.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8597-5_20
Abstract: We introduced the vascular remodeling mouse system induced by the wire injury to investigate the molecular and cellular mechanisms of cardiovascular diseases. Using these models, we focus on the adventitial cell population in the outermost… read more here.
Keywords: artery; wire; vascular remodeling; adventitial lineage ... See more keywords
Reactive Oxygen Species in COPD-Related Vascular Remodeling.
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DOI: 10.1007/978-3-319-63245-2_26
Abstract: The pathogenesis of chronic obstructive pulmonary disease (COPD) is a multifaceted process involving the alteration of pulmonary vasculature. Such vascular remodeling can be associated with inflammation, shear stress, and hypoxia-conditions commonly seen in patients with… read more here.
Keywords: oxygen; reactive oxygen; oxygen species; related vascular ... See more keywords
Toll-like receptor 4 mediates vascular remodeling in hyperhomocysteinemia
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DOI: 10.1007/s11010-017-3026-9
Abstract: Although hyperhomocysteinemia (HHcy) is known to promote downstream pro-inflammatory cytokine elevation, the precise mechanism is still unknown. One of the possible receptors that could have significant attention in the field of hypertension is toll-like receptor… read more here.
Keywords: like receptor; toll like; remodeling hyperhomocysteinemia; vascular remodeling ... See more keywords
Omeprazole induces vascular remodeling by mechanisms involving xanthine oxidoreductase and matrix metalloproteinase activation.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114633
Abstract: Proton pump inhibitors (PPI) are commonly used drugs that may increase the cardiovascular risk by mechanisms not entirely known. We examined whether the PPI omeprazole promotes vascular oxidative stress mediated by xanthine oxidoreductase (XOR) leading… read more here.
Keywords: induces vascular; vascular remodeling; omeprazole induces; xor ... See more keywords
Therapeutic potential of carbon monoxide in hypertension-induced vascular smooth muscle cell damage revisited: from physiology and pharmacology.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115008
Abstract: As a chronic and progressive disorder, hypertension remains to be a serious public health problem around the world. Among the different types of hypertension, pulmonary arterial hypertension (PAH) is a devastating disease associated with pulmonary… read more here.
Keywords: hypertension induced; carbon monoxide; physiology; vascular remodeling ... See more keywords
An emerging strategy for targeted therapy of pulmonary arterial hypertension: vasodilation plus vascular remodeling inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discovery today"
DOI: 10.1016/j.drudis.2022.01.011
Abstract: Pulmonary arterial hypertension (PAH) is a rapidly progressing disease with limited therapeutic options. Studies have elucidated the multifactorial pathological characteristics of PAH, indicating the complexity and difficulty of PAH treatment. Currently available treatments focus primarily… read more here.
Keywords: pah; arterial hypertension; pulmonary arterial; vascular remodeling ... See more keywords
Vascular remodeling: A redox‐modulated mechanism of vessel caliber regulation
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DOI: 10.1016/j.freeradbiomed.2017.01.025
Abstract: ABSTRACT Vascular remodeling, i.e. whole‐vessel structural reshaping, determines lumen caliber in (patho)physiology. Here we review mechanisms underlying vessel remodeling, with emphasis in redox regulation. First, we discuss confusing terminology and focus on strictu sensu remodeling.… read more here.
Keywords: tensional homeostasis; vessel; redox; remodeling redox ... See more keywords
Nitrite treatment downregulates vascular MMP‐2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects
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DOI: 10.1016/j.freeradbiomed.2018.11.002
Abstract: ABSTRACT Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)− 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non‐antihypertensive dose exerts antioxidant effects and attenuates… read more here.
Keywords: remodeling hypertension; vascular mmp; vascular remodeling; hypertension ... See more keywords
Early treatment with losartan effectively ameliorates hypertension and improves vascular remodeling and function in a prehypertensive rat model
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DOI: 10.1016/j.lfs.2017.01.013
Abstract: Aims: Pharmacological treatment of prehypertension may ameliorate hypertension and improve vascular structure and function. This study investigated 1) whether early treatment with either losartan or amlodipine at the onset of prehypertension can prevent hypertension and… read more here.
Keywords: treatment; losartan; remodeling function; vascular remodeling ... See more keywords
Flavin adenine dinucleotide ameliorates hypertensive vascular remodeling via activating short chain acyl-CoA dehydrogenase.
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DOI: 10.1016/j.lfs.2020.118156
Abstract: AIMS Flavin adenine dinucleotide (FAD), participates in fatty acid β oxidation as a cofactor, which has been confirmed to enhance SCAD activity and expression. However, the role of FAD on hypertensive vascular remodeling is unclear.… read more here.
Keywords: adenine dinucleotide; dinucleotide ameliorates; hypertensive vascular; flavin adenine ... See more keywords