Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09812-7
Abstract: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure and death. Disturbed transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signalling, endothelial cell dysfunction,… read more here.
Keywords: vascular remodelling; tgf signalling; inhibition; bmp signalling ... See more keywords
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.09.031
Abstract: Background and aims Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The… read more here.
Keywords: vascular remodelling; subclinical vascular; associated snp; mendelian randomisation ... See more keywords
Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-κB signalling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111005
Abstract: In addition to serving as an incretin-based treatment of type 2 diabetes mellitus (T2DM), glucagon-like peptide 1 (GLP-1) can also reverse cardiovascular diseases caused by vascular remodelling. However, a detailed mechanism underlying how GLP-1 reverses… read more here.
Keywords: vascular remodelling; glucagon like; matrix metalloproteinase; reverses vascular ... See more keywords
Elevated expression of placental growth factor is associated with airway-wall vascular remodelling and thickening in smokers with asthma
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43017
Abstract: The increased expression of placental growth factor (PlGF) in chronic obstructive pulmonary disease and allergy-related asthma suggests its role in the pathogenesis of these diseases. In asthmatic smokers, airway remodelling is accompanied by an accelerated… read more here.
Keywords: vascular remodelling; plgf; placental growth; airway wall ... See more keywords
Dual effects of fructose on ChREBP and FoxO1/3α are responsible for AldoB up-regulation and vascular remodelling.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20160251
Abstract: Increased production of methylglyoxal (MG) in vascular tissues is one of the causative factors for vascular remodelling in different subtypes of metabolic syndrome, including hypertension and insulin resistance. Fructose-induced up-regulation of aldolase B (AldoB) contributes… read more here.
Keywords: vascular remodelling; foxo1; aldob regulation; fructose induced ... See more keywords
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of hypertension"
DOI: 10.1097/hjh.0000000000003399
Abstract: OBJECTIVES Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme in the fatty acid oxidation process, is not only involved in ATP synthesis but also regulates the production of mitochondrial reactive oxygen species (ROS) and nitric oxide… read more here.
Keywords: scad expression; chain acyl; vascular remodelling; short chain ... See more keywords
Isoquercitrin protects against pulmonary hypertension via inhibiting PASMCs proliferation
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12705
Abstract: Pulmonary vascular remodelling is a common feature among the heterogeneous disorders that cause pulmonary arterial hypertension (PAH), and pulmonary arterial smooth muscle cells (PASMCs) proliferation impact the long‐term prognosis of the patient. Isoquercitrin (IQC) is… read more here.
Keywords: vascular remodelling; iqc; proliferation; pasmcs proliferation ... See more keywords
The role of Hippo/yes‐associated protein signalling in vascular remodelling associated with cardiovascular disease
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13806
Abstract: Vascular remodelling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and… read more here.
Keywords: vascular remodelling; associated protein; yes associated; signalling vascular ... See more keywords
Sex‐specific and hormone‐related differences in vascular remodelling in atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13885
Abstract: Atherosclerosis, a lipid‐driven inflammatory disease, is the main underlying cause of cardiovascular diseases (CVDs) both in men and women. Sex‐related dimorphisms regarding CVDs and atherosclerosis were observed since more than a decade ago. Inflammatory mediators… read more here.
Keywords: sex; atherosclerosis; sex specific; vascular remodelling ... See more keywords
Circular RNAs Regulate Vascular Remodelling in Pulmonary Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/4433627
Abstract: Circular RNAs (circRNAs) are a newly identified type of noncoding RNA molecule with a unique closed-loop structure. circRNAs are widely expressed in different tissues and developmental stages of many species, participating in many important pathophysiological… read more here.
Keywords: rnas regulate; pulmonary hypertension; circular rnas; regulate vascular ... See more keywords
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022179
Abstract: The large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling… read more here.
Keywords: pi3k akt; ctrp7; large conductance; calcium activated ... See more keywords