Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation
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DOI: 10.1002/advs.202203995
Abstract: Vascular smooth muscle cells (SMCs) can adapt to changes in cellular geometric cues; however, the underlying mechanisms remain elusive. Using 2D micropatterned substrates to engineer cell geometry, it is found that in comparison with an… read more here.
Keywords: dna; muscle cells; geometry; vascular smooth ... See more keywords
Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis
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DOI: 10.1002/advs.202204038
Abstract: Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is a pore‐forming effector of pyroptosis. In this study, the role of… read more here.
Keywords: muscle cells; abdominal aortic; vascular smooth; aortic aneurysm ... See more keywords
ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure
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DOI: 10.1002/advs.202408811
Abstract: Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA‐binding protein that regulates mRNA stability by binding to adenylate‐uridylate‐rich elements… read more here.
Keywords: blood pressure; smooth muscle; zfp36; vascular smooth ... See more keywords
Npom‐Protected NONOate Enables Light‐Triggered NO/cGMP Signalling in Primary Vascular Smooth Muscle Cells
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DOI: 10.1002/cbic.201700683
Abstract: Diazeniumdiolates (NONOates) are a class of nitric‐oxide‐releasing substances widely used in studies of NO/cGMP signalling. Because spatiotemporal control is highly desirable for such purposes, we have synthesised a new Npom‐caged pyrrolidine NONOate. A kinetic analysis… read more here.
Keywords: vascular smooth; cgmp signalling; muscle cells; npom protected ... See more keywords
The role of tribbles homolog 2 in vascular smooth muscle cell proliferation
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DOI: 10.1002/cbin.11982
Abstract: Tribbles homolog 2 (TRIB2) functions as an adapter protein that regulates signal transductions involved in a variety of cellular functions, including tumorigenesis. However, the role of TRIB2 in the proliferation of vascular smooth muscle cells… read more here.
Keywords: cell; proliferation; role; expression ... See more keywords
Obesity‐Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility
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DOI: 10.1002/cph4.70053
Abstract: Inter‐organ crosstalk, particularly between adipose tissue and vasculature, plays a key role in obesity‐induced cardiovascular dysfunction. Our previous work showed that adipose‐derived extracellular vesicles (adiposomes) from obese donors impair arteriolar vasodilation through endothelial dysfunction, but… read more here.
Keywords: obesity; muscle cell; smooth muscle; vascular smooth ... See more keywords
Chemical imaging of fresh vascular smooth muscle cell response by epi-detected stimulated Raman scattering.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biophotonics"
DOI: 10.1002/jbio.201700005
Abstract: An understanding of deformation of cardiovascular tissue under hemodynamic load is crucial for understanding the health and disease of blood vessels. In the present work, an epi-detected stimulated Raman scattering (epi-SRS) imaging platform was designed… read more here.
Keywords: raman scattering; detected stimulated; stimulated raman; vascular smooth ... See more keywords
Linear ubiquitination modification of NR6A1 by LUBAC inhibits RIPK3 kinase activity and attenuates apoptosis of vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23091
Abstract: Nuclear receptor subfamily 6 group A member 1 (NR6A1) is involved in promoting the apoptotic process of vascular smooth muscle cells (VSMCs) which is a critical process involved in atherosclerosis, but the action mechanism remains… read more here.
Keywords: lubac; apoptosis; muscle cells; vascular smooth ... See more keywords
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis
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DOI: 10.1002/jcb.29272
Abstract: In this study, we established both an animal model and a cellular model of hyperuricemia (HUC). Subsequently, we treated these models with allopurinol (ALLO) to study the effect of uric acid (UA) and ALLO on… read more here.
Keywords: osteoblasts vascular; vascular smooth; muscle cells; proliferation osteoblasts ... See more keywords
MasR and pGCA receptor activation protects primary vascular smooth muscle cells and endothelial cells against oxidative stress via inhibition of intracellular calcium.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30422
Abstract: Cardiovascular diseases (CVDs) are associated with vascular smooth muscle cell (VSMC) and endothelial cell (EC) damage. Angiotensin1-7 (Ang1-7) and B-type natriuretic peptide (BNP) are responsible for vasodilation and regulation of blood flow. These protective effects of BNP are primarily… read more here.
Keywords: stress; smooth muscle; oxidative stress; vascular smooth ... See more keywords
Visualization of stimulus‐specific heterogeneous activation of individual vascular smooth muscle cells in aortic tissues
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25903
Abstract: Intercellular communication among autonomic nerves, endothelial cells (ECs), and vascular smooth muscle cells (VSMCs) plays a central role in an uninterrupted regulation of blood flow through vascular contractile machinery. Impairment of this communication is linked… read more here.
Keywords: vascular smooth; muscle cells; smooth muscle; activation ... See more keywords