Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2016.12.004
Abstract: Chemically-induced vascular toxicity during embryonic development may cause a wide range of adverse effects. To identify putative vascular disrupting chemicals (pVDCs), a predictive pVDC signature was constructed from 124 U.S. EPA ToxCast high-throughput screening (HTS)… read more here.
Keywords: screening angiogenic; vascular toxicity; angiogenic inhibitors; pvdc signature ... See more keywords
Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.694711
Abstract: Vascular toxicity is a frequent adverse effect of current anticancer chemotherapies and often results from endothelial dysfunction. Vascular endothelial growth factor inhibitors (VEGFi), anthracyclines, plant alkaloids, alkylating agents, antimetabolites, and radiation therapy evoke vascular toxicity.… read more here.
Keywords: vascular toxicity; updates anticancer; toxicity; anticancer therapy ... See more keywords
[The in vivo imaging of zebrafish for chemical vascular toxicity assessment].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]"
DOI: 10.3760/cma.j.cn112150-20210510-00457
Abstract: Objective: To evaluate the vascular toxicity of chemicals by a real-time observation approach using the transgenic zebrafish. Methods: The spatiotemporal vascular alterations of transgenic zebrafish after chemical exposure were assessed by laser confocal microscopy and… read more here.
Keywords: vascular toxicity; assessment; zebrafish chemical; microscopy ... See more keywords