Does Vascular Endothelial Cell or Smooth Muscle Affect the Decrease in Oxygen Consumption of Arteriolar Wall During Vasodilation?
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DOI: 10.1007/978-3-319-91287-5_41
Abstract: Our previous studies demonstrated that vascular wall oxygen consumption rate (QO2) of arteriole under in vivo functional condition was dramatically greater than that reported by isolated vascular segment. Furthermore, such high QO2 of vascular wall… read more here.
Keywords: vascular wall; vasodilation; wall; smooth muscle ... See more keywords
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation.
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DOI: 10.1007/s11357-021-00455-6
Abstract: Our past study showed that coronary arterioles isolated from adipose-derived stromal vascular fraction (SVF)-treated rats showed amelioration of the age-related decrease in vasodilation to beta-adrenergic receptor (β-AR) agonist and improved β-AR-dependent coronary flow and microvascular… read more here.
Keywords: vasodilation; grk2; svf; receptor ... See more keywords
Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.036
Abstract: BACKGROUND Advanced glycation endproducts (AGEs) play a major role in the development of many vascular complications that are mediated by endothelial dysfunction. The present work aimed to investigate the mechanism by which AGEs impair vasodilation.… read more here.
Keywords: vasodilation; vasodilation induced; effect; advanced glycation ... See more keywords
An emerging strategy for targeted therapy of pulmonary arterial hypertension: vasodilation plus vascular remodeling inhibition.
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DOI: 10.1016/j.drudis.2022.01.011
Abstract: Pulmonary arterial hypertension (PAH) is a rapidly progressing disease with limited therapeutic options. Studies have elucidated the multifactorial pathological characteristics of PAH, indicating the complexity and difficulty of PAH treatment. Currently available treatments focus primarily… read more here.
Keywords: pah; arterial hypertension; pulmonary arterial; vascular remodeling ... See more keywords
SKA‐31, an activator of endothelial Ca2+‐activated K+ channels evokes robust vasodilation in rat mesenteric arteries
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.006
Abstract: Abstract It is now well recognized that endothelial KCa2.3 and KCa3.1 channel activities contribute to dilation of resistance arteries via endothelium‐mediated hyperpolarization and vascular smooth muscle relaxation. In this study, we have investigated the functional… read more here.
Keywords: kca2 kca3; vasodilation; mesenteric arteries; channel ... See more keywords
Vasodilation activity of dipfluzine metabolites in isolated rat basilar arteries and their underlying mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2020.103430
Abstract: Identifying the metabolites of a drug has become an indispensable task in the development of new drugs. Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases and has 5 metabolites (M1∼M5)… read more here.
Keywords: rat basilar; vasodilation; basilar arteries; dip ... See more keywords
8-methoxysmyrindiol from Gerbera piloselloides (L.) Cass. and its vasodilation effects on isolated rat mesenteric arteries.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.104299
Abstract: Gerbera piloselloides (L.) Cass. (Compositae) possesses various biological effects. It is used as an oriental remedy for relieving cough and resolving phlegm. The present study is to investigate the vasodilation effects of Gerbera piloselloides on… read more here.
Keywords: piloselloides cass; vasodilation effects; vasodilation; gerbera piloselloides ... See more keywords
Endothelial TRP channels and cannabinoid receptors are involved in affinin-induced vasodilation.
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DOI: 10.1016/j.fitote.2021.104985
Abstract: Affinin is mainly recognized by its antinociceptive effect. Recently, our research group demonstrated that this compound produces vasodilation via activation of the gasotransmitters signaling pathways. However, the molecular targets of affinin were not identified. Considering… read more here.
Keywords: affinin induced; trp channels; induced vasodilation; vasodilation ... See more keywords
Inhaled carbon monoxide increases vasodilation in the microvascular circulation.
Sign Up to like & getrecommendations! Published in 2019 at "Microvascular research"
DOI: 10.1016/j.mvr.2019.01.004
Abstract: Preeclampsia (PE) is characterized by systemic maternal endothelial dysfunction. Changes in endothelial reactivity have been reported before the onset of clinical signs of PE, and continuing into the post-partum period. Women who smoke during pregnancy… read more here.
Keywords: monoxide increases; carbon monoxide; vasodilation; inhaled carbon ... See more keywords
KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults.
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DOI: 10.1016/j.mvr.2020.104096
Abstract: OBJECTIVE To examine the contributions of calcium-activated K+ (KCa) channels and nitric oxide synthase (NOS) to adenosine triphosphate (ATP)-induced cutaneous vasodilation in healthy older adults. METHODS In eleven older adults (69 ± 2 years, 5… read more here.
Keywords: induced cutaneous; vasodilation; kca channels; cutaneous vasodilation ... See more keywords
Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice
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DOI: 10.1016/j.vph.2018.01.002
Abstract: Vascular dysfunction in small resistance arteries is observed during chronic elevations in blood glucose. Hyperglycaemia-associated effects on endothelium-dependent vasodilation have been well characterized, but effects on conducted vasodilation in the resistance vasculature are not known.… read more here.
Keywords: vasculature; conducted vasodilation; vasodilation resistance; vasodilation ... See more keywords