Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced.
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DOI: 10.1152/japplphysiol.00483.2017
Abstract: Nitric oxide (NO)-mediated vasodilation contributes to the rapid rise in muscle blood flow at exercise onset. This occurs via increased cyclic guanosine monophosphate (cGMP), which is catabolized by phosphodiesterase-5 (PDE-5). Whether PDE-5 limits exercise vasodilation… read more here.
Keywords: onset kinetics; inhibition; vasodilation; exercise onset ... See more keywords