Chimpanzee Personality and the Arginine Vasopressin Receptor 1A Genotype
Sign Up to like & getrecommendations! Published in 2017 at "Behavior Genetics"
DOI: 10.1007/s10519-016-9822-2
Abstract: Polymorphisms of the arginine vasopressin receptor 1a (AVPR1a) gene have been linked to various measures related to human social behavior, including sibling conflict and agreeableness. In chimpanzees, AVPR1a polymorphisms have been associated with traits important… read more here.
Keywords: genotype; sex; personality; arginine vasopressin ... See more keywords
Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00011
Abstract: Prevailing strategies directing early-phase drug discovery heavily rely on equilibrium-based metrics such as affinity, which overlooks the kinetic process of a drug molecule interacting with its target. Herein, we developed a number of vasopressin V2… read more here.
Keywords: polycystic kidney; vasopressin receptor; residence time; autosomal dominant ... See more keywords
Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00567
Abstract: Cyst formation and enlargement in autosomal dominant kidney disease (ADPKD) is mainly driven by aberrantly increased cytosolic cAMP in renal tubule epithelial cells. Because the vasopressin V2 receptor (V2R) regulates intracellular cAMP levels in kidneys,… read more here.
Keywords: dominant kidney; kidney; benzodiazepine derivatives; vasopressin receptor ... See more keywords
Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors
Sign Up to like & getrecommendations! Published in 2018 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0120-z
Abstract: Genome-wide association studies (GWAS) of complex, heritable, behavioral phenotypes have yielded an incomplete accounting of the genetic influences. The identified loci explain only a portion of the observed heritability, and few of the loci have… read more here.
Keywords: short tandem; receptor avpr1a; tandem repeats; arginine vasopressin ... See more keywords
Vasopressin receptor antagonists: a patent summary (2018-2022).
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2023.2218546
Abstract: INTRODUCTION Arginine-vasopressin hormone (AVP) is a key regulator in many essential physiological processes. The effect of AVP is mediated through three receptors within the body, these are the G protein-coupled vasopressin receptors, namely V1a, V1b… read more here.
Keywords: receptor antagonists; vasopressin receptor; 2018 2022; antagonists patent ... See more keywords
Bioavailability and pharmacokinetic profile of balovaptan, a selective, brain-penetrant vasopressin 1a receptor antagonist, in healthy volunteers
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2021.1948009
Abstract: ABSTRACT Background Balovaptan is a potent, selective vasopressin 1a receptor antagonist. The early-phase pharmacokinetics (PK) of balovaptan are reported. Research design and methods Two Phase 1 studies (overall N = 93) assessed single- and multiple-dose… read more here.
Keywords: receptor antagonist; day; balovaptan; vasopressin receptor ... See more keywords
Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-12-0818
Abstract: For a prototypical GPCR, the human vasopressin receptor type 2 (V2R), βarr1 can form a stable complex associated via only the phosphorylated carboxyl terminus of the receptor. Such a partially engaged complex is functionally competent… read more here.
Keywords: arrestin dispensable; engagement arrestin; activation; receptor ... See more keywords
Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.811836
Abstract: The urine concentrating function of the kidney is essential to maintain the water homeostasis of the human body. It is mainly regulated by the arginine-vasopressin (AVP), which targets the type 2 vasopressin receptor (V2R) in… read more here.
Keywords: nephrogenic diabetes; v2r; vasopressin; vasopressin receptor ... See more keywords
Natural Peptide Toxins as an Option for Renewed Treatment of Type 2 Vasopressin Receptor-Related Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12040544
Abstract: Simple Summary The type 2 vasopressin receptor is a perfect representative of therapeutic targets that are underexploited due to the lack of safe and effective drugs. This receptor is well-known in terms of physiological roles… read more here.
Keywords: type vasopressin; vasopressin; vasopressin receptor; type ... See more keywords
Polymorphisms in Oxytocin and Vasopressin Receptor Genes as a Factor Shaping the Clinical Picture and the Risk of ASD in Males
Sign Up to like & getrecommendations! Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13040689
Abstract: Autism spectrum disorders (ASD) are a heterogeneous group of disorders affecting virtually every population, regardless of their ethnic or socioeconomic background. Their pathogenesis is multifactorial, based on interactions between genetic and environmental factors. The key… read more here.
Keywords: asd; clinical picture; vasopressin receptor; risk ... See more keywords