The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23548
Abstract: The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is controlled by small GTPases of the RhoA family. Here, we report that Vav3, a Rho… read more here.
Keywords: guanine nucleotide; nucleotide exchange; remyelination; exchange factor ... See more keywords
Targeting HuR-Vav3 mRNA interaction prevents Pseudomonas aeruginosa adhesion to the cystic fibrosis airway epithelium
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DOI: 10.1172/jci.insight.161961
Abstract: Cystic fibrosis (CF) is characterized by chronic bacterial infections leading to progressive bronchiectasis and respiratory failure. Pseudomonas aeruginosa (Pa) is the predominant opportunistic pathogen infecting the CF airways. The guanine nucleotide exchange factor Vav3 plays… read more here.
Keywords: hur; adhesion; vav3 mrna; vav3 ... See more keywords
The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1042403
Abstract: Oligodendrocyte precursor cells (OPCs) are the exclusive source of myelination in the central nervous system (CNS). Prior to myelination, OPCs migrate to target areas and mature into myelinating oligodendrocytes. This process is underpinned by drastic… read more here.
Keywords: precursor cells; vav3; nucleotide exchange; guanine nucleotide ... See more keywords