Genetic Deficiency of MicroRNA-15a/16-1 Confers Resistance to Neuropathological Damage and Cognitive Dysfunction in Experimental Vascular Cognitive Impairment and Dementia.
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DOI: 10.1002/advs.202104986
Abstract: Chronic cerebral hypoperfusion-derived brain damage contributes to the progression of vascular cognitive impairment and dementia (VCID). Cumulative evidence has shown that microRNAs (miRs) are emerging as novel therapeutic targets for CNS disorders. In this study,… read more here.
Keywords: impairment dementia; vcid; damage; vascular cognitive ... See more keywords
Tau Hyperphosphorylation in Brain Microvasculature: Relevance to Vascular Cognitive Impairment & Dementia (VCID)
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DOI: 10.1152/physiol.2023.38.s1.5731480
Abstract: Current evidence suggests that cerebrovascular dysfunction including compromised BBB integrity and decreased CBF are early findings before the development of neuronal pathologies and cognitive deficits in VCID. Hyperphosphorylated tau (p-tau) is historically associated with the… read more here.
Keywords: rich diet; tau; vcid; brain ... See more keywords
Pharmacological inhibition of SPAK-NKCC1 complex attenuates astrogliosis and restores cerebral blood flow in a mouse model of VCID
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DOI: 10.1186/s40478-025-02137-2
Abstract: Vascular contributions to cognitive impairment and dementia (VCID) are one of the leading causes of dementia, where reactive astrogliosis, blood-brain barrier (BBB) disruption, and white matter lesions (WML) are the key features. However, the molecular… read more here.
Keywords: spak; bcas; vcid; astrogliosis ... See more keywords
A review of SaiLuoTong (MLC-SLT) development in vascular cognitive impairment and dementia
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DOI: 10.3389/fphar.2024.1343820
Abstract: The dementia epidemic, attributed to aging populations, represents a growing socio-economic burden. It is estimated that in 2019 about 55 million people worldwide were living with dementia. With many possible causes of dementia and the… read more here.
Keywords: dementia; mlc slt; vcid; development ... See more keywords