Tau accumulation is cleared by the induced expression of VCP via autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica"
DOI: 10.1007/s00401-024-02804-z
Abstract: Tauopathy, including frontotemporal lobar dementia and Alzheimer’s disease, describes a class of neurodegenerative diseases characterized by the aberrant accumulation of Tau protein due to defects in proteostasis. Upon generating and characterizing a stable transgenic zebrafish… read more here.
Keywords: expression vcp; accumulation; tau; vcp ... See more keywords
Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.107745
Abstract: Summary Spatiotemporal protein reorganization at DNA damage sites induced by genotoxic chemotherapies is crucial for DNA damage response (DDR), which influences treatment response by directing cancer cell fate. This process is orchestrated by valosin-containing protein… read more here.
Keywords: chemotherapy; dna damage; response; cancer ... See more keywords
Structural insight into mutations at 155 position of valosin containing protein (VCP) linked to inclusion body myopathy with Paget disease of bone and frontotemporal Dementia
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.048
Abstract: Mutations in Valosin-containing protein (VCP) have been implicated in the pathology linked to inclusion body myopathy, paget disease of bone and frontotemporal dementia (IBMPFD). VCP is an essential component of AAA-ATPase superfamily involved in various… read more here.
Keywords: protein; valosin containing; protein vcp; vcp ... See more keywords
Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species
Sign Up to like & getrecommendations! Published in 2020 at "Virus Research"
DOI: 10.1016/j.virusres.2020.197974
Abstract: Abstract Valosin-containing protein (VCP) plays roles in various cellular activities. Recently, Enterovirus A71 (EVA71) infection was found to hijack the VCP protein. However, the mechanism by which VCP participates in the EVA71 life cycle remains… read more here.
Keywords: enterovirus; infection; vcp ufd1; vcp ... See more keywords
The functional importance of VCP to maintaining cellular protein homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220648
Abstract: The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. VCP primarily… read more here.
Keywords: importance vcp; maintaining cellular; functional importance; vcp maintaining ... See more keywords
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2052461
Abstract: ABSTRACT The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely unexplored. In this study,… read more here.
Keywords: recruitment vcp; wipi2; damaged mitochondria; vcp ... See more keywords
Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz119
Abstract: Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease characterized by a progressive decline in motor function. Genetic analyses have identified several genes mutated in ALS patients, and one of them is Cyclin F… read more here.
Keywords: atpase activity; cyclin; gene ccnf; vcp ... See more keywords
BTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf626
Abstract: Abstract Skin exposure to UV rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery. The inefficient repair of photolesions can lead to stalled… read more here.
Keywords: repair; vcp; vcp p97; btg3 ... See more keywords
Pharmacy Use in the First Year of the Veterans Choice Program: A Mixed-methods Evaluation
Sign Up to like & getrecommendations! Published in 2017 at "Medical Care"
DOI: 10.1097/mlr.0000000000000661
Abstract: Background: The Veterans Choice Program (VCP) was created to ensure timely access to health care in the Department of Veterans Affairs (VA). Under this program, medications may be ordered by select non-VA clinicians to be… read more here.
Keywords: use; first year; program; veterans choice ... See more keywords
Right‐sided vocal cord paralysis following stereotactic body radiation therapy for non–small‐cell lung cancer: A case report
Sign Up to like & getrecommendations! Published in 2023 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14905
Abstract: Vocal code paralysis (VCP) is a rare complication of stereotactic body radiation therapy (SBRT). In most previously reported cases of VCP after SBRT, VCP was left‐sided because of anatomic vulnerability. Here, we report a case… read more here.
Keywords: lung cancer; right sided; lung; vcp ... See more keywords
A Retrotranslocation Assay That Predicts Defective VCP/p97-Mediated Trafficking of a Retroviral Signal Peptide
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02953-21
Abstract: Endoplasmic reticulum-associated degradation (ERAD) is a form of cellular protein quality control that is manipulated by viruses, including the betaretrovirus, mouse mammary tumor virus (MMTV). MMTV-encoded signal peptide (SP) has been shown to interact with… read more here.
Keywords: mmtv; signal peptide; retrotranslocation; vcp ... See more keywords