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   Articles with "vcp p97" as a keyword



VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy

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recommendations! Published in 2024 at "Autophagy"

DOI: 10.1080/15548627.2024.2356488

Abstract: ABSTRACT Macroautophagy/autophagy is essential for the degradation and recycling of cytoplasmic materials. The initiation of this process is determined by phosphatidylinositol-3-kinase (PtdIns3K) complex, which is regulated by factor BECN1 (beclin 1). UFMylation is a novel… read more here.

Keywords: p97 ufmylation; vcp p97; ufmylation; ufmylation stabilizes ... See more keywords

BTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf626

Abstract: Abstract Skin exposure to UV rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery. The inefficient repair of photolesions can lead to stalled… read more here.

Keywords: repair; vcp; vcp p97; btg3 ... See more keywords

The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50

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recommendations! Published in 2020 at "Journal of Virology"

DOI: 10.1128/jvi.00110-20

Abstract: Targeting the endoplasmic reticulum (ER) by viral proteins may affect ER-associated protein homeostasis. During human cytomegalovirus (HCMV) infection, pUL50 targets the ER through its transmembrane domain and moves to the inner nuclear membrane (INM) to… read more here.

Keywords: loss; ul50 p26; pul50; vcp p97 ... See more keywords

A Retrotranslocation Assay That Predicts Defective VCP/p97-Mediated Trafficking of a Retroviral Signal Peptide

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.02953-21

Abstract: Endoplasmic reticulum-associated degradation (ERAD) is a form of cellular protein quality control that is manipulated by viruses, including the betaretrovirus, mouse mammary tumor virus (MMTV). MMTV-encoded signal peptide (SP) has been shown to interact with… read more here.

Keywords: mmtv; signal peptide; retrotranslocation; vcp ... See more keywords