Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23326
Abstract: Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats each were used for this… read more here.
Keywords: sirt1 pgc; vincristine; vcr; levels nrf2 ... See more keywords
Evaluation of variable compression ratio (VCR) and variable valve timing (VVT) strategies in a heavy-duty diesel engine with reactivity controlled compression ignition (RCCI) combustion under a wide load range
Sign Up to like & getrecommendations! Published in 2019 at "Fuel"
DOI: 10.1016/j.fuel.2019.05.020
Abstract: Variable compression ratio (VCR)and variable valve timing (VVT)are two effective strategies to adjust the effective compression ratio, which is beneficial for controlling the combustion process of advanced combustion modes. In this study, systematic evaluation of… read more here.
Keywords: vcr; compression; vvt strategies; compression ratio ... See more keywords
Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1496746
Abstract: ABSTRACT We recently reported that primary acute lymphoblastic leukemia (ALL) cells are susceptible to the microtubule depolymerizing agent vincristine (VCR) in G1 phase. This finding prompted testing another G1 phase-active compound, palbociclib (PCB), a highly… read more here.
Keywords: phase; lymphoblastic leukemia; primary acute; acute lymphoblastic ... See more keywords
Vitreous Cortex Remnants Removal with Beveled vitrectomy probe during Vitrectomy for Primary Rhegmatogenous retinal detachment.
Sign Up to like & getrecommendations! Published in 2023 at "Retina"
DOI: 10.1097/iae.0000000000003779
Abstract: PURPOSE To introduce a new surgical technique with a beveled vitrectomy probe for the removal of peripheral vitreous cortex remnants (VCR) in primary rhegmatogenous retinal detachment (RRD). METHODS This study was a retrospective case series.… read more here.
Keywords: retinal detachment; vcr; beveled vitrectomy; vitrectomy probe ... See more keywords
Abstract 2801: Pharmacokinetic modeling of Vincristine and its metabolite in Kenyan pediatric cancer patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2801
Abstract: This feasibility study aimed to establish the logistically feasible protocol for the Phase I trial in Kenyan pediatric cancer patients. The trial’s ultimate goal is to rationally optimize the dosing of the anti-cancer drug, Vincristine… read more here.
Keywords: pediatric cancer; vcr; cancer patients; kenyan pediatric ... See more keywords
Vincristine-Loaded Platelets Coated with Anti-CD41 MAbs: A New Proposal for the Treatment of Immune Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.2319.2319
Abstract: Objective: Immune thrombocytopenia (ITP) is an autoimmune disorder in which platelet-reactive autoantibodies accelerate the destruction of platelets. Macrophages play a crucial role in ITP through IgG-Fcγ receptor-mediated platelet clearance. Patients responding to initial therapies often… read more here.
Keywords: platelets coated; cd41 vlp; coated anti; cd41 ... See more keywords
New mechanistic insight on the PIM-1 kinase inhibitor AZD1208 using multidrug resistant human erythroleukemia cell lines and molecular docking simulations.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190509121606
Abstract: PIM-1 is a kinase which has been related to the oncogenic processes like cell survival, proliferation and multidrug resistance (MDR). This kinase is known for its ability to phosphorylate the main extrusion pump (ABCB1) related… read more here.
Keywords: dnr; pim kinase; pim; cell ... See more keywords
Prevention and Healing of Calcium Signaling Mediated Neuronal Damage on successive Administration of Flavonoid Enriched Pterocarpus Marsupium Roxb in Peripheral Neuropathy Model
Sign Up to like & getrecommendations! Published in 2020 at "Current Bioactive Compounds"
DOI: 10.2174/1573407216666200218112305
Abstract: Modern research on peripheral neuropathy circumstance utter that treatments with Vincristine (VCR) disturb the microtubular cells in sensory and motor neurons due to calcium over- load in sciatic nerve, unfortunately, VCR triggering the release of… read more here.
Keywords: flavonoid enriched; peripheral neuropathy; vcr induced; calcium ... See more keywords
Efficacy analysis of targeted nanodrug for non-small cell lung cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1068699
Abstract: Biological macromolecules have been widely used as biomedical carriers in treating non-small cell lung cancer (NSCLC) due to their biocompatibility, targeting, biodegradability, and antitumor efficacy. Nanotechnology has been used in clinics to treat many diseases,… read more here.
Keywords: non small; vcr; efficacy; small cell ... See more keywords
Clinical Efficacy and Dosing of Vibrotactile Coordinated Reset Stimulation in Motor and Non-motor Symptoms of Parkinson's Disease: A Study Protocol
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.758481
Abstract: Enhanced neuronal synchronization of the subthalamic nucleus (STN) is commonly found in PD patients and corresponds to decreased motor ability. Coordinated reset (CR) was developed to decouple synchronized states causing long lasting desynchronization of neural… read more here.
Keywords: study; non motor; coordinated reset; vcr ... See more keywords
Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.901000
Abstract: Background: Vincristine (VCR) is used in the clinic as an anti-tumor drug. VCR can cause pulmonary fibrosis (PF), leading to respiratory failure. The transformation of fibroblasts into myofibroblasts may play a key role in PF.… read more here.
Keywords: vcr; erk1; expression; mapk ... See more keywords