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   Articles with "vcz" as a keyword



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Variability of voriconazole concentrations in patients with hematopoietic stem cell transplantation and hematological malignancies: influence of loading dose, procalcitonin, and pregnane X receptor polymorphisms

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recommendations! Published in 2020 at "European Journal of Clinical Pharmacology"

DOI: 10.1007/s00228-020-02831-1

Abstract: Aims Voriconazole (VCZ) displays highly variable pharmacokinetics affecting treatment efficacy and safety. We aimed to identify the factors affecting VCZ steady-state trough concentration (Cssmin) to provide evidence for optimizing VCZ treatment regimens. Methods A total… read more here.

Keywords: cssmin; hematopoietic stem; pxr; vcz ... See more keywords
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Prediction Models for Voriconazole Pharmacokinetics Based on Pharmacogenetics: An Exploratory Study in Spanish population.

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recommendations! Published in 2019 at "International journal of antimicrobial agents"

DOI: 10.1016/j.ijantimicag.2019.06.026

Abstract: Individualization of the therapeutic strategy for the oral antifungal voriconazole (VCZ) is extremely important for treatment optimization. To date, regulatory agencies include CYP2C19 as the only major pharmacogenetics (PGx) biomarker in their dosing guidelines; however,… read more here.

Keywords: models voriconazole; study; prediction models; voriconazole pharmacokinetics ... See more keywords
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Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring.

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recommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"

DOI: 10.1016/j.jpba.2019.112952

Abstract: Abstract • Voriconazole (VCZ) is highly efficient in the treatment of invasive fungal infections. However, the therapy requires the monitoring of VCZ plasma concentration, due to a narrow therapeutic index and large inter-individual variability of… read more here.

Keywords: determination total; plasma; total free; study ... See more keywords

Vinclozolin-induced mouse penile malformation and "small testis" via miR132, miR195a together with the Hippo signaling pathway.

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recommendations! Published in 2021 at "Toxicology"

DOI: 10.1016/j.tox.2021.152842

Abstract: Vinclozolin (VCZ) is a fungicide with antiandrogen activity. Exposure to VCZ in maternal uterus may cause uterine, ovarian and testicular damage, hypospadias and prostate abnormality in the offspring. Hippo pathway, which is highly conservative and… read more here.

Keywords: penile malformation; mir132 mir195a; vinclozolin; vcz ... See more keywords
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Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation

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recommendations! Published in 2021 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.717932

Abstract: Many factors have been described to contribute to voriconazole (VCZ) interpatient variability in plasma concentrations, especially CYP2C19 genetic variability. In 2014, Hicks et al. presented data describing the correlation between VCZ plasma concentrations and CYP2C19… read more here.

Keywords: initial dose; target concentrations; preemptive genotyping; vcz ... See more keywords
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Inflammation Affects Liver Function and the Metabolism of Voriconazole to Voriconazole-N-Oxide in Adult and Elderly Patients

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.835871

Abstract: Background: The inner association of inflammation with voriconazole (VCZ) metabolism has not been fully investigated. We intend to investigate the effects of inflammation on liver function, VCZ trough concentration (C0), C0/dose ratio and the ratio… read more here.

Keywords: vcz; metabolism; elderly patients; adult elderly ... See more keywords
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Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients

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recommendations! Published in 2023 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2023.1126580

Abstract: Background: Voriconazole (VCZ) metabolism is influenced by many factors. Identifying independent influencing factors helps optimize VCZ dosing regimens and maintain its trough concentration (C0) in the therapeutic window. Methods: We conducted a prospective study investigating… read more here.

Keywords: factors influencing; younger adult; elderly patients; concentration ... See more keywords