Novel insights into role of miR‐320a‐VDAC1 axis in astrocyte‐mediated neuronal damage in neuroAIDS
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23089
Abstract: Astroglia are indispensable component of the tripartite synapse ensheathing innumerous soma and synapses. Its proximity to neurons aids the regulation of neuronal functions, health and survival through dynamic neuroglia crosstalk. Susceptibility of astrocyte to HIV‐1… read more here.
Keywords: hiv; vdac1; hiv tat; atp release ... See more keywords
VDAC1 as a target in cisplatin anti-tumor activity through promoting mitochondria fusion.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.104
Abstract: Cisplatin is one of the most effective anti-cancer drugs, but its efficacy is limited by the development of resistance. Previous studies have shown that mitochondria play critical roles in cisplatin cytotoxicity, however, the exact mechanism… read more here.
Keywords: vdac1 target; cisplatin; vdac1; fusion ... See more keywords
A Ca2+ chelator ameliorates chromium (VI)-induced hepatocyte L-02 injury via down-regulation of voltage-Dependent anion channel 1 (VDAC1) expression.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2016.11.007
Abstract: Hexavalent chromium could result in cell malfunctions. Intracellular Ca2+ ([Ca2+]i) content and VDAC1 expression are both important features related to cell survial. This study aimed to explore the mechanism of cell injury induced by Cr(VI)… read more here.
Keywords: vdac1 expression; vdac1; ca2; injury ... See more keywords
Regulation of VDAC1 contributes to the cardioprotective effects of penehyclidine hydrochloride during myocardial ischemia/reperfusion
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.004
Abstract: ABSTRACT Penehyclidine hydrochloride (PHC) preconditioning can alleviate myocardial ischemia/reperfusion (I/R) injury and inhibits the upregulation of voltage‐dependent anion channel 1 (VDAC1) during I/R. To validate that VDAC1 is a bona fide target of PHC for… read more here.
Keywords: overexpression; penehyclidine hydrochloride; cardioprotective effects; myocardial ischemia ... See more keywords
Structure and Gating Behavior of the Human Integral Membrane Protein VDAC1 in a Lipid Bilayer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09848
Abstract: The voltage-dependent anion channel (VDAC), the most abundant protein in the outer mitochondrial membrane, is responsible for the transport of all ions and metabolites into and out of mitochondria. Larger than any of the β-barrel… read more here.
Keywords: vdac1; structure; microscopy; lipid bilayer ... See more keywords
Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02205-y
Abstract: Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on… read more here.
Keywords: binary complex; complex formation; vdac1; formation ... See more keywords
Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2121821
Abstract: Abstract The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear. Small-molecule ligands specifically interacting… read more here.
Keywords: vdac1; microscale thermophoresis; fluorimetry microscale; differential scanning ... See more keywords
The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1711317
Abstract: ABSTRACT The TLK1/Nek1 axis contributes to cell cycle arrest and implementation of the DDR to mediate survival upon DNA damage. However, when the damage is too severe, the cells typically are forced into apoptosis, and… read more here.
Keywords: tlk1; apoptosis; vdac1; integrity ... See more keywords
VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2150001
Abstract: Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infection in insect vectors without causing… read more here.
Keywords: vdac1; apoptosis; mitophagy apoptosis; infection ... See more keywords
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2182482
Abstract: Mitophagy, which selectively eliminates the dysfunctional and excess mitochondria by autophagy, is crucial for cellular homeostasis under stresses such as hypoxia. Dysregulation of mitophagy has been increasingly linked to many disorders including neurodegenerative disease and… read more here.
Keywords: vdac1; hypoxia induced; hypoxia; mitophagy ... See more keywords
A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13663
Abstract: Alzheimer's disease (AD) is the most common cause of mental dementia in the aged population. AD is characterized by the progressive decline of memory and multiple cognitive functions, and changes in behavior and personality. Recent… read more here.
Keywords: vdac1; tau mice; mitophagy autophagy; mice ... See more keywords