Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.
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DOI: 10.1016/j.bbrc.2018.10.050
Abstract: Sulindac sulfone is a metabolite of sulindac, a non-steroidal anti-inflammatory drug (NSAID), without anti-inflammatory ability. However, sulindac sulfone has been reported to significantly reduce polyps in patients with colorectal adenomatous polyposis in clinical trials. Thus,… read more here.
Keywords: vdac1 vdac2; sulindac sulfone; sulfone; colon cancer ... See more keywords