Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomolecular NMR"
DOI: 10.1007/s10858-019-00242-8
Abstract: The second isoform of the human voltage dependent anion channel (VDAC2) is a mitochondrial porin that translocates calcium and other metabolites across the outer mitochondrial membrane. VDAC2 has been implicated in cardioprotection and plays a… read more here.
Keywords: human membrane; nmr structural; lipid bilayers; vdac2 ... See more keywords
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adr8146
Abstract: Defective apoptosis mediated by B cell lymphoma 2 antagonist/killer (BAK) or B cell lymphoma 2–associated X protein (BAX) underlies various pathologies including autoimmune and degenerative conditions. On mitochondria, voltage-dependent anion channel 2 (VDAC2) interacts with… read more here.
Keywords: vdac2; bax bak; wehi 3773; bax ... See more keywords
Abstract 2541: Heterogeneity of VDAC2-Bak/Bax mediated mitochondrial apoptosis can be exploited to develop effective and selective treatment against metastatic uveal melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2541
Abstract: Apoptosis, a form of programmed cell death, is an evolutionarily conserved and genetically regulated phenomenon that is pivotal in maintaining tissue homeostasis and is an important player in regulating carcinogenesis. Mitochondria along with its resident… read more here.
Keywords: apoptosis; vdac2; vdac2 bak; treatment ... See more keywords