Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25679
Abstract: Epidemiological and clinical data suggest adverse cardiovascular outcomes with respect to vitamin D deficiency. Here, we explored the effects of vitamin D in atherosclerotic plaque calcification in vivo by utilizing vitamin D receptor (Vdr)‐deficient mice… read more here.
Keywords: vdr; calcification; mice; plaque calcification ... See more keywords
The role of vitamin D receptor and IL-6 in COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.2172
Abstract: BACKGROUND Vitamin D (Vit.D) has an important role in protecting COVID-19 patients. This study investigated the changes in vitamin D receptor (VDR) expression and interleukin 6 levels in patients with COVID-19. MATERIALS AND METHODS 120… read more here.
Keywords: role; vdr; vitamin receptor; expression ... See more keywords
Exosomal miR‐122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23365
Abstract: This study examined the effects of miR‐122–enriched exosomes on the expression of vitamin D3 receptor (VDR) and sterol regulatory element‐binding transcription factor 1 (SREBF1) and their roles during adipogenesis. read more here.
Keywords: 122 promotes; obesity; exosomal mir; vdr ... See more keywords
Transgenic Mice Overexpressing Vitamin D Receptor (VDR) Show Anti-Inflammatory Effects in Lung Tissues
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0641-2
Abstract: Vitamin D insufficiency is increasingly recognized as a prevalent problem worldwide, especially in patients with a chronic lung disease. Chronic obstructive pulmonary disease (COPD) is a type of chronic inflammatory lung disease. Previous clinical studies… read more here.
Keywords: anti inflammatory; inflammatory effects; vdr; mice ... See more keywords
Influence of Stress on the Vitamin D-Vitamin D Receptor System, Macrophages, and the Local Inflammatory Milieu in Endometriosis
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00235-1
Abstract: We previously demonstrated the negative impact of stress in an animal model of endometriosis. Although its role is unclear, altered levels of vitamin D (VitD) have been found in patients with this condition. VitD signaling… read more here.
Keywords: endometriosis; vdr; local inflammatory; stress ... See more keywords
Promoter hypermethylation regulates vitamin D receptor (VDR) expression in colorectal cancer-A study from Kashmir valley.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2021.01.002
Abstract: BACKGROUND Colorectal carcinogenesis (CRC) is a multistep process, involving both genetic and epigenetic modifications of genes involved in diverse pathways ranging from tumor suppression to DNA mismatch repair. PURPOSE This study was undertaken to assess… read more here.
Keywords: methylation; vdr; study; expression ... See more keywords
Vitamin D Switches BAF Complexes to Protect β Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.04.013
Abstract: A primary cause of disease progression in type 2 diabetes (T2D) is β cell dysfunction due to inflammatory stress and insulin resistance. However, preventing β cell exhaustion under diabetic conditions is a major therapeutic challenge. Here,… read more here.
Keywords: vitamin switches; vdr; baf; association ... See more keywords
Association of SNP‐SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Breast Cancer"
DOI: 10.1016/j.clbc.2018.09.004
Abstract: Micro‐Abstract Genetic susceptibility for breast cancer (BC) is still poorly understood. We investigated the association of single nucleotide polymorphism (SNP)‐SNP interactions of 6 SNPs in RANKL, OPG, CHI3L1, and VDR genes with BC risk in… read more here.
Keywords: risk; vdr; chi3l1; vdr genes ... See more keywords
Antagonistic effect of VDR/CREB1 pathway on cadmium-induced apoptosis in porcine spleen.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111819
Abstract: Cadmium (Cd) is a toxic trace element that can enter the environment with industrial waste and accumulate in the body but the health effects of Cd on ternary pigs are still lacking in research. In… read more here.
Keywords: vdr; apoptosis; creb1 pathway; induced apoptosis ... See more keywords
Vitamin D receptor (VDR) contributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming (GHS) rat model
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.09.001
Abstract: Abstract Human idiopathic hypercalciuria (IH) is the most common cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption, which can be phenotype-copied in the genetic hypercalciuric… read more here.
Keywords: hypercalciuria; development; receptor; calcium ... See more keywords
RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e02837
Abstract: Vitamin D receptor (VDR) is a nuclear receptor for 1,25-Dihydroxyvitamin D3. VDR is expressed in many types of cells and involved in different biological processes such as immunity and inflammation. In addition, the role for… read more here.
Keywords: vdr; cell lines; cell growth; jurkat ... See more keywords