Talimogene Laherparepvec for Treating Metastatic Melanoma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Sign Up to like & getrecommendations! Published in 2017 at "PharmacoEconomics"
DOI: 10.1007/s40273-017-0504-6
Abstract: The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Amgen) of talimogene laherparepvec (T-VEC) to submit clinical and cost-effectiveness evidence for previously untreated advanced (unresectable or metastatic) melanoma as part of the… read more here.
Keywords: melanoma; company; treatment; evidence ... See more keywords
Fermi surface volume of interacting systems
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Physics"
DOI: 10.1016/j.aop.2019.03.016
Abstract: Three Fermion sumrules for interacting systems are derived at T=0, involving the number expectation $\bar{N}(\mu)$, canonical chemical potentials $\mu(m)$, a logarithmic time derivative of the Greens function $\gamma_{\vec{k} \sigma}$ and the static Greens function. In… read more here.
Keywords: fermi surface; vec; interacting systems; vec sigma ... See more keywords
Surface electronic structure and elastic property of (Ti,Zr)(C,N) coatings by laser carburization
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DOI: 10.1016/j.ceramint.2020.06.150
Abstract: Abstract Change in the mechanical properties of (Ti,Zr)(C,N) coatings by laser carburization was investigated in terms of bonding state and valence electron concentration (VEC). The doped carbon was analyzed for the formation of amorphous carbon… read more here.
Keywords: vec; coatings laser; surface electronic; gpa ... See more keywords
Highly safe and cyclable Li-metal batteries with vinylethylene carbonate electrolyte
Sign Up to like & getrecommendations! Published in 2020 at "Nano Energy"
DOI: 10.1016/j.nanoen.2020.104860
Abstract: Abstract Safety concerns impede the deployment of Li-metal batteries, while the highly flammable electrolytes make main contribution to the hazard caused by the reactive Li with electrolytes. Fire-extinguishing electrolytes do exist, but their introductions into… read more here.
Keywords: electrolyte highly; electrolyte; vinylethylene carbonate; metal batteries ... See more keywords
Superconductivity in high and medium entropy alloys based on MoReRu
Sign Up to like & getrecommendations! Published in 2019 at "Physica C: Superconductivity and its Applications"
DOI: 10.1016/j.physc.2019.1353520
Abstract: Abstract Hexagonal close-packed (HCP) high entropy or medium entropy alloys (HEAs or MEAs) based on alterations of the ternary superconductor Mo.33Re.33Ru.33 (valence electron count VEC = 7/atom) are tested for their potential superconductivity. Quaternary Mo.25Re.25Ru.25Rh.25 has VEC… read more here.
Keywords: entropy; entropy alloys; medium entropy; vec ... See more keywords
Is There Still a Role for Talimogene Laherparepvec (T-VEC) in Advanced Melanoma? An Indirect Efficacy Comparison of T-VEC Plus Ipilimumab Combination Therapy versus T-VEC Alone as Salvage Therapy in Unresectable Metastatic Melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on biological therapy"
DOI: 10.1080/14712598.2022.1998450
Abstract: BACKGROUND Talimogene laherparepvec (T-VEC) improves overall survival (OS) in unresectable stage IIIB/C-IV melanoma.1 T-VEC may have synergistic effects with CTLA-4 inhibitors.2 In the absence of a trial comparing T-VEC and ipilimumab (T-VEC+IPI) to T-VEC, we… read more here.
Keywords: melanoma; versus vec; ipi; therapy ... See more keywords
Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE)
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1615817
Abstract: ABSTRACT Pexastimogene devacirepvec (Pexa-Vec) is a vaccinia virus-based oncolytic immunotherapy designed to preferentially replicate in and destroy tumor cells while stimulating anti-tumor immunity by expressing GM-CSF. An earlier randomized Phase IIa trial in predominantly sorafenib-naïve… read more here.
Keywords: pexa vec; trial; pexastimogene devacirepvec; vec ... See more keywords
Noether currents of locally equivalent symmetries
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DOI: 10.1088/1402-4896/ab50a5
Abstract: Local symmetry transformations play an important role for establishing the existence and form of a conserved (Noether) current in systems with a global continuous symmetry. We explain how this fact leads to the existence of… read more here.
Keywords: equivalent symmetries; locally equivalent; noether currents; momentum ... See more keywords
On the behaviour of the two-dimensional Hamiltonian $-\,{\rm{\Delta }}+\lambda [\delta (\vec{x}+{\vec{x}}_{0})+\delta (\vec{x}-{\vec{x}}_{0})]$ as the distance between the two centres vanishes
Sign Up to like & getrecommendations! Published in 2020 at "Physica Scripta"
DOI: 10.1088/1402-4896/ab8f3f
Abstract: In this note we continue our analysis of the behaviour of self-adjoint Hamiltonians with a pair of identical point interactions symmetrically situated around the origin perturbing various types of "free Hamiltonians" as the distance between… read more here.
Keywords: distance; delta; vec vec; delta vec ... See more keywords
Talimogene laherparepvec monotherapy for head and neck melanoma patients
Sign Up to like & getrecommendations! Published in 2022 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000866
Abstract: Talimogene laherparepvec (T-VEC) is a modified herpes simplex virus, type 1, intralesionally administered in patients with stage IIIB/C-IVM1a unresectable melanoma. When surgery is not a treatment option in the head and neck region, T-VEC can… read more here.
Keywords: response; vec; head neck; melanoma ... See more keywords
Double parton distribution of valence quarks in the pion in chiral quark models
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DOI: 10.1103/physrevd.101.014019
Abstract: The valence double parton distribution of the pion is analyzed in the framework of chiral quark models, where in the chiral limit factorization between the longitudinal and transverse degrees of freedom occurs. This feature leads,… read more here.
Keywords: double parton; valence; vec; distribution ... See more keywords