Subpial AAV Delivery for Spinal Parenchymal Gene Regulation in Adult Mammals.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9139-6_12
Abstract: The use of adeno-associated virus (AAV) vectors has become an attractive method for treatment of a variety of neurodegenerative disorders by permitting targeted gene upregulation or silencing in the CNS. Systemic and intrathecal infusion, while… read more here.
Keywords: technique; vector delivery; adult; delivery ... See more keywords
Lobe-Specific Gene Vector Delivery to Rat Lungs Using a Miniature Bronchoscope.
Sign Up to like & getrecommendations! Published in 2018 at "Human gene therapy methods"
DOI: 10.1089/hgtb.2018.050
Abstract: For respiratory research utilizing gene vector delivery to the lung, the size of rodent models has typically necessitated relatively "blind" dosing via the nose, via an endotracheal tube, or through a surgical incision into the… read more here.
Keywords: gene vector; vector delivery; gene; rat lungs ... See more keywords
Viral Vector Delivery of DREADDs for CNS Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Current gene therapy"
DOI: 10.2174/1566523221666210211102435
Abstract: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are genetically modified G-protein-coupled receptors (GPCRs), which can be activated by a synthetic ligand that is otherwise inert at endogenous receptors. DREADDs can be expressed in cells… read more here.
Keywords: dreadds; vector delivery; viral vector; delivery ... See more keywords