Inhibition of Neointima Hyperplasia, Inflammation, and Reactive Oxygen Species in Balloon-Injured Arteries by HVJ Envelope Vector-Mediated Delivery of Superoxide Dismutase Gene
Sign Up to like & getrecommendations! Published in 2018 at "Translational Stroke Research"
DOI: 10.1007/s12975-018-0660-9
Abstract: Extracellular superoxide dismutase (EC-SOD) has been implicated in regulation of vascular function but its underlying molecular mechanism is largely unknown. These two-step experiments investigate whether hemagglutinating virus of Japan envelope (HVJ-E) vector-mediated EC-SOD gene delivery… read more here.
Keywords: vector; delivery; inflammation; vector mediated ... See more keywords
AAV vector-mediated in vivo reprogramming into pluripotency
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05059-x
Abstract: In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4,… read more here.
Keywords: vivo reprogramming; vector; vector mediated; aav vector ... See more keywords
Applications of Virus Vector-Mediated Gene Therapy in China.
Sign Up to like & getrecommendations! Published in 2017 at "Human Gene Therapy"
DOI: 10.1089/hum.2017.238
Abstract: Due to the increased safety and efficiency of virus vectors, virus vector–mediated gene therapy is now widely used for various diseases, including monogenic diseases, complex disorders, and infectious diseases. Recent gene therapy trials have shown… read more here.
Keywords: mediated gene; gene therapy; virus vector; vector mediated ... See more keywords
Intranasal Lentiviral Vector-Mediated Antibody Delivery Confers Reduction of SARS-CoV-2 Infection in Elderly and Immunocompromised Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.819058
Abstract: Vaccines for COVID-19 are now a crucial public health need, but the degree of protection provided by conventional vaccinations for individuals with compromised immune systems is unclear. The use of viral vectors to express neutralizing… read more here.
Keywords: cov infection; vector mediated; sars cov; mice ... See more keywords
Viral Vector-Mediated Antisense Therapy for Genetic Diseases
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DOI: 10.3390/genes8020051
Abstract: RNA plays complex roles in normal health and disease and is becoming an important target for therapeutic intervention; accordingly, therapeutic strategies that modulate RNA function have gained great interest over the past decade. Antisense oligonucleotides… read more here.
Keywords: antisense therapy; viral vector; mediated antisense; vector mediated ... See more keywords