Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104674
Abstract: Venezuelan equine encephalitis virus (VEEV) is an alphavirus that is endemic to the Americas. VEEV outbreaks occur periodically and cause encephalitis in both humans and equids. There are currently no therapeutics or vaccines for treatment… read more here.
Keywords: rna synthesis; encephalitis; veev; ml336 inhibits ... See more keywords
Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Structural Biology"
DOI: 10.1016/j.jsb.2019.02.008
Abstract: Abstract Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus which can be involved in several central nervous system disorders such as encephalitis and meningitis. The VEEV genome codes for 4 non-structural proteins (nsP),… read more here.
Keywords: binding adp; macro domain; veev; macro ... See more keywords
Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus
Sign Up to like & getrecommendations! Published in 2017 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-017-2355-3
Abstract: BackgroundVenezuelan equine encephalitis virus (VEEV) is an alphavirus in the family Togaviridae. VEEV causes a bi-phasic illness in mice where primary replication in lymphoid organs is followed by entry into the central nervous system (CNS).… read more here.
Keywords: response; v3034; infection; encephalitis ... See more keywords
Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections
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DOI: 10.3390/pathogens10030283
Abstract: Alphaviruses are a genus of the Togaviridae family and are widely distributed across the globe. Venezuelan equine encephalitis virus (VEEV) and eastern equine encephalitis virus (EEEV), cause encephalitis and neurological sequelae while chikungunya virus (CHIKV)… read more here.
Keywords: ha15; inhibitor; host; veev ... See more keywords
Tumour Necrosis Factor-α, Chemokines, and Leukocyte Infiltrate Are Biomarkers for Pathology in the Brains of Venezuelan Equine Encephalitis (VEEV)-Infected Mice
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15061307
Abstract: Venezuelan equine encephalitis virus (VEEV) is a disease typically confined to South and Central America, whereby human disease is characterised by a transient systemic infection and occasionally severe encephalitis, which is associated with lethality. Using… read more here.
Keywords: venezuelan equine; disease; equine encephalitis; encephalitis ... See more keywords