Minimal physiologically‐based pharmacokinetic model to investigate the effect of pH dependent FcRn affinity and the endothelial endocytosis on the pharmacokinetics of anti‐VEGF humanized IgG1 antibody in cynomolgus monkey
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DOI: 10.1016/j.ejps.2018.09.015
Abstract: &NA; In this study, we developed a first minimal physiologically‐based pharmacokinetic (mPBPK) model to investigate the complex interaction effects of endocytosis rate/FcRn binding affinity at both acidic/physiological pH on the pharmacokinetics (PK) of the anti‐VEGF… read more here.
Keywords: anti vegf; igg1; model; fcrn ... See more keywords