Retinal Microvasculature-on-a-Chip for Modeling VEGF-Induced Permeability.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2217-9_18
Abstract: Relevant human in vitro models of the retinal microvasculature can be used to study the role of disease mediators on retinal barrier dysfunction and assess the efficacy of early drug candidates. This chapter describes an… read more here.
Keywords: induced permeability; vegf induced; retinal microvasculature; microvasculature ... See more keywords
Evaluating VEGF-Induced Vascular Leakage Using the Miles Assay.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2217-9_21
Abstract: Before the endothelial mitogenic activity of the Vascular Endothelial Growth Factor A (VEGF) was described, VEGF had already been identified for its ability to induce vascular leakage. VEGF-induced vascular leakage has been most frequently studied… read more here.
Keywords: using miles; induced vascular; vegf induced; vascular leakage ... See more keywords
Taurocholic acid inhibits features of age-related macular degeneration in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.107974
Abstract: Previous metabolomics studies from our lab found altered plasma levels of bile acids in patients with age-related macular degeneration (AMD) compared to controls. In this study, we investigated the ability of the bile acid taurocholic… read more here.
Keywords: vegf; age related; related macular; vegf induced ... See more keywords
Lutein and zeaxanthin attenuates VEGF-induced neovascularisation in human retinal microvascular endothelial cells through a Nox4-dependent pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108104
Abstract: Age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR) are two of the most common and severe causes of vision loss in the population. Both conditions are associated with excessive levels of vascular endothelial growth… read more here.
Keywords: retinal microvascular; induced neovascularisation; vegf induced; lutein zeaxanthin ... See more keywords
Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2019.01.002
Abstract: Although didymin, a dietary flavonoid glycoside from citrus fruits, known to be a potent antioxidant with anti-cancer activities, its role in angiogenesis is not known. In this study, we examined the effect of didymin on… read more here.
Keywords: vegf; vivo; didymin; induced angiogenesis ... See more keywords
Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Natural Medicines"
DOI: 10.1016/s1875-5364(22)60159-6
Abstract: Angiogenesis inhibitors targeting VEGF signaling pathway could be developed into drugs for the treatment of several diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent study has revealed that oleanolic acid (OA), a… read more here.
Keywords: vegf induced; huvecs; vegfr2; proliferation ... See more keywords
Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/1052102
Abstract: Increased side toxicities and development of drug resistance are the major concern for the cancer chemotherapy using synthetic drugs. Therefore, identification of novel natural antioxidants with potential therapeutic efficacies is important. In the present study,… read more here.
Keywords: edible mushroom; neovascularization vitro; vialinin; vegf induced ... See more keywords
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5888636
Abstract: Brevilin A (BA), a sesquiterpene lactone isolated from Centipeda minima herb, has been identified to exhibit potent anticancer activity. However, the potential pharmacological effect and mechanism of BA in regulating endothelial cell (EC) angiogenesis, a… read more here.
Keywords: brevilin; mitochondrial dysfunction; vegf induced; ros ... See more keywords
Abstract 4598: Vitamin b1 derivative, benfotamine, prevents VEGF-induced angiogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4598
Abstract: Several studies have indicated that thiamine, and more specifically its lipid soluble derivative benfotiamine, exerts an anti-oxidative and anti-inflammatory effect on the body. However, its effect in preventing cancer cell proliferation, migration, invasion, and metastasis… read more here.
Keywords: prevents vegf; induced angiogenesis; benfotiamine; vegf induced ... See more keywords
VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.315931
Abstract: Supplemental Digital Content is available in the text. Objective: VEGF (vascular endothelial growth factor) plays a critical role in physiological and pathological angiogenesis. Endothelial 3D podosomes (3DPs) are a type of F-actin-rich membrane microdomain, predominantly… read more here.
Keywords: expression; vegf induced; endothelial podosomes; sprouting angiogenesis ... See more keywords
Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.207605
Abstract: ABSTRACT Vascular endothelial growth factor (VEGF), a key angiogenic and permeability factor, plays an important role in new blood vessel formation. However, abnormal VEGF-induced VEGFR2 signaling leads to hyperpermeability. We have shown previously that Rap1,… read more here.
Keywords: cell; endothelial barrier; vegf induced; permeability ... See more keywords