6,7‐Dimethoxy‐Quinazolin‐4‐yl‐Amino‐Nicotinamide Derivatives as Potent Inhibitors of VEGF Receptor II
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DOI: 10.1002/jhet.2750
Abstract: The sprouting of new blood vessels, or angiogenesis, is necessary for any solid tumor to grow large enough to cause life-threatening disease. Vascular endothelial growth factor (VEGF) is one of the key promoters of tumor-induced… read more here.
Keywords: quinazolin amino; vegf receptor; dimethoxy quinazolin;
The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma
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DOI: 10.1038/bjc.2017.418
Abstract: Rachna T Shroff, Mark Yarchoan, Ashley O’Connor, Denise Gallagher, Marianna L Zahurak, Gary Rosner, Chimela Ohaji, Susan Sartorius-Mergenthaler, Rose Parkinson, Vivek Subbiah, Ralph Zinner and Nilofer S Azad The University of Texas MD Anderson Cancer… read more here.
Keywords: inhibitor; vegf receptor; receptor tyrosine; cancer center ... See more keywords
VEGF Receptor-2 Activation Mediated by VEGF-E Limits Scar Tissue Formation Following Cutaneous Injury.
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DOI: 10.1089/wound.2016.0721
Abstract: Objective: Vascular endothelial growth factor (VEGF) family members are critical regulators of tissue repair and depending on their distinct pattern of receptor specificity can also promote inflammation and scarring. This study utilized a receptor-selective VEGF… read more here.
Keywords: vegf; tissue; formation; vegf receptor ... See more keywords
VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types
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DOI: 10.1371/journal.pone.0269818
Abstract: Purpose We have previously reported that VEGF-B is more potent than VEGF-A in mediating corneal nerve growth in vitro and in vivo, and this stimulation of nerve growth appears to be different from stimulation of… read more here.
Keywords: cell; microscopy; vegf receptor; endothelial cell ... See more keywords
The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice
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DOI: 10.14336/ad.2016.0920
Abstract: The mechanism by which angiogenesis declines with aging is not fully understood. Soluble vascular endothelial growth factor receptor 1 (VEGFR1) form (sFlt1) contributes to endothelial dysfunction in pathological conditions. However, the roles of sFlt1 in… read more here.
Keywords: sflt; soluble vegf; vegf receptor; neovascularization ... See more keywords