6,7-Dimethoxy-quinazolin-4-yl-amino-thiophene-2-carboxamides as Potent Inhibitors of VEGF Receptors 1 and 2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2675
Abstract: The identification of agents with antiproliferative activity against endothelial cells has significant value for the treatment of many angiogenesis-dependent pathologies. The vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors… read more here.
Keywords: thiophene carboxamides; vegf receptors; dimethoxy quinazolin; quinazolin amino ... See more keywords
Imaging VEGF Receptors and αvβ3 Integrins in a Mouse Hindlimb Ischemia Model of Peripheral Arterial Disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-018-1191-1
Abstract: PurposeTo compare targeted imaging of vascular endothelial growth factor (VEGF) receptors vs. αvβ3 integrins in a mouse hindlimb ischemia model of peripheral artery disease.ProceduresMale wild-type (WT) C57BL/6 mice (8- to 10-week old) (n = 24) underwent left… read more here.
Keywords: vegf receptors; mouse hindlimb; ischemia model; hindlimb ischemia ... See more keywords
Molecular docking and interactions between vascular endothelial growth factor (VEGF) receptors and phytochemicals: An in-silico study
Sign Up to like & getrecommendations! Published in 2019 at "Biocatalysis and Agricultural Biotechnology"
DOI: 10.1016/j.bcab.2019.101424
Abstract: Abstract Vascular endothelial growth factor (VEGF) is a mitogen, which plays a vital role in angiogenesis and neovascularization. Numerous medications have been developed to inhibit VEGF in cancer, because of its significance in tumor development… read more here.
Keywords: vegf receptors; vascular endothelial; endothelial growth; study ... See more keywords
A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14450
Abstract: Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis. Here, we describe how a specific class of EVs, called microvesicles (MVs), activates… read more here.
Keywords: extracellular vesicles; vegf receptors; receptors tumour; activates vegf ... See more keywords