Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis
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DOI: 10.1038/s41598-018-33014-9
Abstract: Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes show blunted chemotactic responses… read more here.
Keywords: dysfunction; src kinase; vegf resistance; shp src ... See more keywords
Metformin therapy as a strategy to compensate anti-VEGF resistance in patients with diabetic macular edema
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DOI: 10.1097/md.0000000000031266
Abstract: Diabetic macular edema (DME) is the complication of diabetic retinopathy, the leading cause of vision loss among diabetic patients. Metformin is the main antidiabetic treatment. It is preferable for its great anti-angiogenic and anti-inflammatory effects.… read more here.
Keywords: vegf; anti vegf; metformin; vegf resistance ... See more keywords