Effective treatment of retinal neovascular leakage with fusogenic porous silicon nanoparticles delivering VEGF-siRNA.
Sign Up to like & getrecommendations! Published in 2023 at "Nanomedicine"
DOI: 10.2217/nnm-2022-0255
Abstract: Aim: To evaluate an intravitreally injected nanoparticle platform designed to deliver VEGF-A siRNA to inhibit retinal neovascular leakage as a new treatment for proliferative diabetic retinopathy and diabetic macular edema. Materials & methods: Fusogenic lipid-coated… read more here.
Keywords: silicon nanoparticles; porous silicon; treatment; leakage ... See more keywords
Preparation and Characterization of Functionalized Graphene Oxide Carrier for siRNA Delivery
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DOI: 10.3390/ijms19103202
Abstract: A successful siRNA delivery system is dependent on the development of a good siRNA carrier. Graphene oxide (GO) has gained great attention as a promising nanocarrier in recent years. It has been reported that GO… read more here.
Keywords: sirna delivery; carrier; vegf; vegf sirna ... See more keywords
Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells
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DOI: 10.3390/pharmaceutics12010039
Abstract: Polyethyleneimine, poly-L-lysine, chitosan and some others cationic polymers have been thoroughly studied as nucleic acid delivery systems in gene therapy. However, the drug release from these systems proceeds at a very low rate due to… read more here.
Keywords: amphiphilic polypeptides; sirna delivery; polypeptides vegf; delivery ... See more keywords
Co-Delivery of Repurposing Itraconazole and VEGF siRNA by Composite Nanoparticulate System for Collaborative Anti-Angiogenesis and Anti-Tumor Efficacy against Breast Cancer
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DOI: 10.3390/pharmaceutics14071369
Abstract: Combinations of two different therapeutic modalities of VEGF inhibitors against angiogenesis can cooperatively impede breast cancer tumor growth and enhance therapeutic efficacy. Itraconazole (ITZ) is a conventional antifungal drug with high safety; however, it has… read more here.
Keywords: efficacy; cancer; anti angiogenesis; vegf sirna ... See more keywords
VEGF siRNA Delivery by a Cancer-Specific Cell-Penetrating Peptide.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1711.11025
Abstract: RNA interference provides an effective tool for developing antitumor therapies. Cell-penetrating peptides (CPPs) are delivery vectors widely used to efficiently transport small-interfering RNA (siRNA) to intracellular targets. In this study, we investigated the efficacy of… read more here.
Keywords: cancer specific; delivery; cell penetrating; cancer ... See more keywords