Optimisation of novel small molecule inhibitors of SRPK1‐mediated VEGF‐A splicing through modelling of permeability properties required for trans‐scleral eye drop delivery
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DOI: 10.1111/j.1755-3768.2017.02612
Abstract: Purpose Development of non-invasive therapies for wAMD and DME has not yet been successful due to poor PK/PD properties. SRPK1 is a novel target that controls VEGF-A splicing. Delivery of potent small molecules to the… read more here.
Keywords: vegf splicing; delivery; permeability; eye ... See more keywords