Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200164
Abstract: Three sets of isatin‐based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell… read more here.
Keywords: schiff bases; qsar studies; vegfr inhibition; based schiff ... See more keywords
Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2016.3792
Abstract: MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro a resistance model… read more here.
Keywords: vegfr inhibition; pan vegfr; using cabozantinib; inhibition ... See more keywords