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   Articles with "vegfr tki" as a keyword



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Clinical impact of early response to first‐line VEGFR‐TKI in patients with metastatic renal cell carcinoma on survival: A multi‐institutional retrospective study

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.5268

Abstract: It remains unknown whether the early response to vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGFR‐TKI) management in malignancies links to long‐term survival. The objective of this study was to investigate the survival rates… read more here.

Keywords: vegfr tki; vegfr tkis; early response; group ... See more keywords
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Outcomes of patients with metastatic clear-cell renal cell carcinoma treated with second-line VEGFR-TKI after first-line immune checkpoint inhibitors.

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recommendations! Published in 2019 at "European journal of cancer"

DOI: 10.1016/j.ejca.2019.04.003

Abstract: BACKGROUND Immune checkpoint inhibitors (ICIs) are being increasingly utilised in the front-line (1L) setting of metastatic clear-cell renal cell carcinoma (mccRCC). Limited data exist on responses and survival on second-line (2L) vascular endothelial growth factor-receptor… read more here.

Keywords: immune checkpoint; checkpoint inhibitors; line; vegfr tki ... See more keywords
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The efficacy of VEGFR TKI therapy after progression on immune combination therapy in metastatic renal cell carcinoma

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recommendations! Published in 2018 at "British Journal of Cancer"

DOI: 10.1038/s41416-018-0104-z

Abstract: BACKGROUNDThe outcome of patients who progress on front-line immune-based combination regimens (IC) including immune checkpoint inhibitors (CPI) and receive subsequent systemic therapy is unknown.MethodsRetrospective analysis of consecutive patients with clear-cell mRCC who progressed on one… read more here.

Keywords: therapy; vegfr tki; tki therapy; combination therapy ... See more keywords
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Frequency and Severity of Hypothyroidism During TKI Therapy in the Pediatric and Young Adult Population

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recommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"

DOI: 10.1097/mph.0000000000002527

Abstract: Tyrosine kinase inhibitors that target vascular endothelial growth factor receptor [VEGFR-TKI] are a class of targeted therapies approved for treatment of several malignancies and are increasingly used in the pediatric population. Development of hypothyroidism during… read more here.

Keywords: young adult; vegfr tki; therapy; tki therapy ... See more keywords
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Cancer associated fibroblasts in Renal Cell Carcinoma: implication in prognosis and resistance to antiangiogenic therapy.

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recommendations! Published in 2021 at "BJU international"

DOI: 10.1111/bju.15506

Abstract: OBJECTIVES To investigate the role of cancer-associated fibroblasts (CAFs) in clear cell renal cell carcinoma (ccRCC) with respect to tumor aggressiveness, metastasis development and resistance to antiangiogenic therapy (VEGFR-tyrosine kinase inhibitors, VEGFR-TKI). METHODS Our study… read more here.

Keywords: cafs; vegfr tki; resistance; cancer associated ... See more keywords
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Outcomes of patients (pts) with metastatic clear-cell renal cell carcinoma (mCCRCC) treated with second-line (2L) vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) after first-line (1L) immune checkpoint inhibitors (ICI).

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recommendations! Published in 2018 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2018.36.6_suppl.682

Abstract: 682Background: Little data exists on objective response rates (ORR), progression-free survival (PFS), and safety of 2L VEGFR-TKI after 1L ICI therapy in pts with mCCRCC. Methods: This is a retrospective study of pts with mCCRCC… read more here.

Keywords: outcomes patients; line; vegfr tki; received nivolumab ... See more keywords
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Extended therapy breaks from VEGFR TKI therapy in renal cell carcinoma: Sometimes less is more

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recommendations! Published in 2018 at "Oncotarget"

DOI: 10.18632/oncotarget.23005

Abstract: The treatment landscape of metastatic renal cell carcinoma (mRCC) dramatically changed with the introduction of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) [1]. Despite major advances in the field of immunotherapy, TKIs… read more here.

Keywords: mrcc; treatment breaks; treatment; vegfr tki ... See more keywords