FGF9‐induced ovarian cancer cell invasion involves VEGF‐A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26820
Abstract: Ovarian cancer (OC) renders its lethality to enhanced metastasis and late detection. A plethora of growth factors including Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) stimulated signaling pathways regulate the invasive/metastatic behavior… read more here.
Keywords: vegf vegfr2; invasion; augmentation; expression ... See more keywords
Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3323-8
Abstract: The combination of carfilzomib, lenalidomide, and dexamethasone (CRd) has induced deep responses in patients with newly diagnosed multiple myeloma. While vascular endothelial growth factor (VEGF) pathway polymorphisms have been associated with clinical outcomes for antiangiogenesis… read more here.
Keywords: related vegf; carfilzomib lenalidomide; response related; response ... See more keywords
Missense Variants in Hypoxia-Induced VEGFA/VEGFR2 Signaling Predict the Outcome of Large Artery Atherosclerotic Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00890-7
Abstract: Collateral density variations are a major determinant of stroke outcome. Here, we explored the association of missense variants in hypoxia-induced VEGFA/VEGFR2 signaling and stroke outcome. We recruited 683 large artery atherosclerotic (LAA) stroke patients as… read more here.
Keywords: vegfa vegfr2; induced vegfa; outcome; missense variants ... See more keywords
Identification of tyrosine kinase inhibitors from Panax bipinnatifidus and Panax pseudoginseng for RTK-HER2 and VEGFR2 receptors, by in silico approach.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10304-5
Abstract: Breast and stomach cancer is reported as a leading cause for human mortality across the world. The overexpression of receptor tyrosine kinase (RTK) proteins, namely the human epidermal growth factor receptor2 (HER2) and the vascular… read more here.
Keywords: kinase inhibitors; vegfr2; her2; her2 vegfr2 ... See more keywords
Biochemical and Conformational Characterization of Recombinant VEGFR2 Domain 7
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biotechnology"
DOI: 10.1007/s12033-019-00211-4
Abstract: Angiogenesis is a biological process finely tuned by a plethora of pro- and anti-angiogenic molecules, among which vascular endothelial growth factors (VEGFs). Their biological activity is expressed through the interaction with three cognate receptor tyrosine… read more here.
Keywords: conformational characterization; characterization recombinant; vegfr2 domain; domain ... See more keywords
Complex Formation between VEGFR2 and the β2-Adrenoceptor
Sign Up to like & getrecommendations! Published in 2019 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2019.02.014
Abstract: Summary Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by… read more here.
Keywords: formation vegfr2; complex formation; vegfr2 adrenoceptor; adrenoceptor ... See more keywords
Brivanib alaninate inhibited dengue virus proliferation through VEGFR2/AMPK pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105721
Abstract: Dengue virus (DENV) is the most prevalent arthropod-borne viral disease of humans and has a major impact on global public health. There is no clinically approved drugs for DENV infection. Since intracellular VEGFR2 is increased… read more here.
Keywords: dengue virus; brivanib alaninate; infection; proliferation ... See more keywords
Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Natural Medicines"
DOI: 10.1016/s1875-5364(22)60159-6
Abstract: Angiogenesis inhibitors targeting VEGF signaling pathway could be developed into drugs for the treatment of several diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent study has revealed that oleanolic acid (OA), a… read more here.
Keywords: vegf induced; huvecs; vegfr2; proliferation ... See more keywords
Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0024-3
Abstract: PEAK1 is a newly described tyrosine kinase and scaffold protein that transmits integrin-mediated extracellular matrix (ECM) signals to facilitate cell movement and growth. While aberrant expression of PEAK1 has been linked to cancer progression, its… read more here.
Keywords: transcription; peak1; kinase; vessel formation ... See more keywords
Genome editing abrogates angiogenesis in vivo
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DOI: 10.1038/s41467-017-00140-3
Abstract: Angiogenesis, in which vascular endothelial growth factor receptor (VEGFR) 2 plays an essential role, is associated with a variety of human diseases including proliferative diabetic retinopathy and wet age-related macular degeneration. Here we report that… read more here.
Keywords: genome editing; editing abrogates; angiogenesis; abrogates angiogenesis ... See more keywords
Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis
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DOI: 10.1038/s41598-019-40626-2
Abstract: Vasculogenesis and angiogenesis are process of formation of blood vessels. Blood vessels are evolved to distribute nutrients and oxygen to distant organs. These vessels are crucial for growth and repair of wounded tissue. During tumor… read more here.
Keywords: blood vessels; angiogenesis; binds atp; vegfr2 ... See more keywords