Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23450
Abstract: Melanoma is a malignant tumor with aggressive behavior. Vemurafenib, a BRAF inhibitor, is clinically used in melanoma, but resistance to melanoma cytotoxic therapies is associated with BRAF mutations. Curcumin can effectively inhibit numerous types of… read more here.
Keywords: resistant melanoma; a375 cells; vemurafenib resistant; melanoma ... See more keywords
Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
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DOI: 10.1038/onc.2016.348
Abstract: BRAF inhibitor (BRAFi) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few months. Understanding the molecular mechanisms underpinning BRAFi-based therapy is therefore an important… read more here.
Keywords: melanoma; gli1 gli2; brafi; vemurafenib resistant ... See more keywords
Analysis of Alternative mRNA Splicing in Vemurafenib-Resistant Melanoma Cells
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DOI: 10.3390/biom12070993
Abstract: Alternative mRNA splicing is common in cancers. In BRAF V600E mutated malignant melanoma a frequent mechanism of acquired resistance to BRAF inhibitors involves alternative splicing (AS) of BRAF. The resulting shortened BRAF protein constitutively dimerizes… read more here.
Keywords: alternative mrna; melanoma; analysis; vemurafenib resistant ... See more keywords
Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance
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DOI: 10.3390/ijms23179910
Abstract: Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic… read more here.
Keywords: cell; resistant melanoma; melanoma; resistance ... See more keywords