Enantioselective Ecotoxicity of Venlafaxine in Aquatic Organisms: Daphnia and Zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5338
Abstract: Venlafaxine is a chiral antidepressant detected in aquatic compartments. It was recently included in the 3rd Watch List from the European Union. The present study aimed to investigate venlafaxine toxicity effects, targeting possible enantioselective effects,… read more here.
Keywords: venlafaxine; organisms daphnia; aquatic organisms; enantioselective ecotoxicity ... See more keywords
Lactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspring
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4389
Abstract: Exposure to selective serotonin reuptake inhibitors can affect hormone‐dependent processes, such as the brain sexual differentiation. Because the use of these antidepressants cause concern during lactation, we evaluated the possible effects of venlafaxine on lactational… read more here.
Keywords: repercussions reproductive; lactational exposure; reproductive parameters; venlafaxine ... See more keywords
The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01563-2
Abstract: A growing body of evidence suggests that depression may be associated with impairment of the tryptophan catabolites (TRYCATs) pathway. The present study investigated the effects of the chronic administration of venlafaxine on the expression and… read more here.
Keywords: tryptophan catabolites; expression methylation; methylation; venlafaxine ... See more keywords
Venlafaxine exerts antidepressant effects possibly by activating MAPK–ERK1/2 and P13K–AKT pathways in the hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.08.011
Abstract: Serotonin noradrenaline reuptake inhibitors are effective antidepressant drugs, which include venlafaxine and duloxetine. Venlafaxine is commonly used in a clinical context, but the molecular biological mechanisms behind its effects have not been fully determined. Here,… read more here.
Keywords: akt; mapk erk1; venlafaxine; erk1 p13k ... See more keywords
Nest-defense behaviors in fathead minnows after lifecycle exposure to the antidepressant venlafaxine.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.11.049
Abstract: Venlafaxine is an antidepressant and anti-anxiety drug that has been detected in municipal wastewater at low μg/L concentrations. In this study, the nest-defense behavior of adult male fathead minnows (Pimephales promelas) was observed in fish… read more here.
Keywords: lifecycle; defense behaviors; venlafaxine; fathead minnows ... See more keywords
Venlafaxine protects against chronic stress-related behaviors in mice by activating the mTORC1 signaling cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.07.096
Abstract: BACKGROUND Recent studies have suggested the role of mammalian target of rapamycin complex 1 (mTORC1) in the pathophysiology of depression. Although venlafaxine was thought to be a serotonin and norepinephrine reuptake inhibitor (SNRI), its pharmacological… read more here.
Keywords: mtorc1 signaling; venlafaxine; mtorc1 system; mtorc1 ... See more keywords
Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: a possible role of EGF.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120069
Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of… read more here.
Keywords: egf; venlafaxine; venlafaxine induced; steroidogenesis ... See more keywords
The effects of analgesics on central processing of tonic pain: A cross-over placebo controlled study
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.06.022
Abstract: Introduction: Opioids and antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) are recognized as analgesics to treat moderate to severe pain, but the central mechanisms underlying their analgesia remain unclear. This study investigated how brain… read more here.
Keywords: tonic pain; spectral indices; venlafaxine; brain ... See more keywords
Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c08379
Abstract: The increasing use of chiral pharmaceuticals has led to their widespread presence in the environment. However, their toxicokinetics have rarely been reported. Therefore, the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers,… read more here.
Keywords: depuration; venlafaxine; uptake depuration; depuration kinetics ... See more keywords
Venlafaxine in Embryos Stimulates Neurogenesis and Disrupts Larval Behavior in Zebrafish.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b04099
Abstract: Venlafaxine, a widely prescribed antidepressant, is a selective serotonin and norepinephrine reuptake inhibitor in humans, and this drug is prevalent in municipal wastewater effluents. While studies have shown that this drug affects juvenile fish behavior,… read more here.
Keywords: venlafaxine; drug; embryos stimulates; venlafaxine embryos ... See more keywords
Green Synthesis of Magnetic Nanocomposite with Iron Oxide Deposited on Cellulose Nanocrystals with Copper (Fe3O4@CNC/Cu): Investigation of Catalytic Activity for the Development of a Venlafaxine Electrochemical Sensor
Sign Up to like & getrecommendations! Published in 2020 at "Industrial & Engineering Chemistry Research"
DOI: 10.1021/acs.iecr.9b06214
Abstract: A screen-printed electrochemical sensor based on Fe3O4@cellulose nanocrystals/Cu nanocomposite (Fe3O4@CNC/Cu) has been constructed for the sensitive detection of venlafaxine. The magnetic Fe3O4@cellulose nanocrystal/Cu nanocomposite was prepared by a green procedure using a plant extract (Petasites… read more here.
Keywords: cnc; fe3o4 cnc; microscopy; venlafaxine ... See more keywords