Novel venom‐derived inhibitors of the human EAG channel, a putative antiepileptic drug target
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.038
Abstract: &NA; Recently, we and other groups revealed that gain‐of‐function mutations in the human ether à go‐go voltage‐gated potassium channel hEAG1 (Kv10.1) lead to developmental disorders with associated infantile‐onset epilepsy. However, the physiological role of hEAG1… read more here.
Keywords: derived inhibitors; human eag; inhibitors human; channel ... See more keywords
Charming the Snake: Venom-Derived Peptides Show Surprising Efficacy as Glycoprotein VI-Targeting Antithrombotic Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.117.309627
Abstract: Snake venoms are potent cocktails containing a diverse array of proteins that typically target neuromuscular junctions or the hemostatic system of the snake’s prey. Many of the venom proteins that target hemostasis adopt a C-type… read more here.
Keywords: venom derived; charming snake; peptides show; derived peptides ... See more keywords
Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1137547
Abstract: Cancer is the second leading cause of death worldwide. Specially, the high incidence rate and prevalence of drug resistance have rendered prostate cancer (PCa) a great threat to men’s health. Novel modalities with different structures… read more here.
Keywords: application; venom derived; toad venom; pca ... See more keywords
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00320
Abstract: Animal venoms are a mixture of peptides and proteins that serve two basic biological functions: predation and defense against both predators and microbes. Antimicrobial peptides (AMPs) are a common component extensively present in various scorpion… read more here.
Keywords: multifunctionality; mesobuthus venom; activity; antimicrobial peptides ... See more keywords
Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092110
Abstract: Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with remarkably longer stability in human serum than the parent Ctn. In this work,… read more here.
Keywords: snake venom; venom derived; derived peptide; examining topoisomers ... See more keywords