Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation.
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DOI: 10.1016/j.thromres.2018.07.015
Abstract: BACKGROUND Hypoxia within acute venous thrombi is thought to drive resolution through stabilisation of hypoxia inducible factor 1 alpha (HIF1α). Prolyl hydroxylase domain (PHD) isoforms are critical regulators of HIF1α stability. Non-selective inhibition of PHD… read more here.
Keywords: resolution; phd; thrombus resolution; venous thrombus ... See more keywords