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   Articles with "ventral hippocampus" as a keyword



Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia.

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recommendations! Published in 2022 at "Developmental psychobiology"

DOI: 10.1002/dev.22283

Abstract: Although individuals with schizophrenia typically present deficits in social interaction, little is known about the quality of their parent-infant interactions. In the present study, we assessed the behavioral effects of neonatal ventral hippocampus lesion (nVHL)… read more here.

Keywords: hippocampus lesion; neonatal ventral; maternal behavior; ventral hippocampus ... See more keywords

Left–right functional asymmetry of ventral hippocampus depends on aversiveness of situations

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recommendations! Published in 2017 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2017.02.028

Abstract: HighlightsThe ventral hippocampus possesses a left–right functional asymmetry in rats.The contribution of each hemisphere depends on the level of aversiveness.Both the left and right VH are activated during weaker anxiety.Only the right VH is activated… read more here.

Keywords: left right; anxiety; functional asymmetry; right functional ... See more keywords

Role of prefrontal cortical 5-HT2A receptors and serotonin transporter in the behavioral deficits in post-pubertal rats following neonatal lesion of the ventral hippocampus

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recommendations! Published in 2020 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2019.112226

Abstract: Neonatal ventral hippocampal-lesioned (NVHL) rats have been shown to display neurochemical and behavioral abnormalities at adulthood, analogous to some of those seen in schizophrenia. Serotonergic neurotransmission is implicated the pathophysiology and treatment of schizophrenia. In… read more here.

Keywords: ht2a; post pubertal; pubertal nvhl; nvhl rats ... See more keywords
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Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus

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recommendations! Published in 2021 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2021.113134

Abstract: In a previous study we showed that Deep Brain Stimulation (DBS) of the rat dorsal subregion of the dorsal raphe (DRD), which sends serotonergic projections to forebrain areas, such as the ventral hippocampus, induces anxiolytic-like… read more here.

Keywords: deep brain; stimulation; dorsal; receptor ... See more keywords

The ventral hippocampus CA3 is critical in regulating timing uncertainty in temporal decision-making.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.108694

Abstract: Timing uncertainty is a critical component of temporal decision-making, as it determines the decision strategies that maximize reward rate. However, little is known about the biological substrates of timing uncertainty. In this study, we report… read more here.

Keywords: uncertainty; temporal decision; timing uncertainty; decision making ... See more keywords

Ventral hippocampal shock encoding modulates the expression of trace cued fear

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recommendations! Published in 2022 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2022.107610

Abstract: The hippocampus is crucial for associative fear learning when the anticipation of threat requires temporal or contextual binding of predictive stimuli as in trace and contextual fear conditioning. Compared with the dorsal hippocampus, far less… read more here.

Keywords: trace; ventral hippocampus; shock; fear ... See more keywords

Ventral hippocampus neurons encode meal-related memory

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59687-1

Abstract: The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates… read more here.

Keywords: memory; meal related; encode meal; ventral hippocampus ... See more keywords

miR-143-3p modulates depressive-like behaviors via Lasp1 in the mouse ventral hippocampus

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-06639-y

Abstract: Depression is a prevalent and intricate mental disorder. The involvement of small RNA molecules, such as microRNAs in the pathogenesis and neuronal mechanisms underlying the depression have been documented. Previous studies have demonstrated the involvement… read more here.

Keywords: like behaviors; ventral hippocampus; depression; depressive like ... See more keywords

Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus

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recommendations! Published in 2024 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2024.2342524

Abstract: ABSTRACT Background Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects of an NPY1R agonist and… read more here.

Keywords: neurogenesis; npy1r agonist; agonist ketamine; ventral hippocampus ... See more keywords

T180. REDUCED [3H]RO15-4513 RECEPTOR BINDING IN THE VENTRAL HIPPOCAMPUS IN THE MAM DEVELOPMENTAL DISRUPTION MODEL OF SCHIZOPHRENIA

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recommendations! Published in 2020 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sbaa029.740

Abstract: Abstract Background Post-mortem studies in schizophrenia patients have repeatedly found abnormalities in the γ-aminobutyric acid (GABA) inhibitory neurotransmission system in the form of parvalbumin (PV)-expressing GABAergic interneuron reduction and aberrant glutamic acid decarboxylase mRNA expression… read more here.

Keywords: schizophrenia; mam; receptor; ventral hippocampus ... See more keywords

Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding

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recommendations! Published in 2019 at "Addiction Biology"

DOI: 10.1111/adb.12624

Abstract: Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine… read more here.

Keywords: hippocampus; morphine; morphine conditioned; reinstatement morphine ... See more keywords