Neonatal ventral hippocampus lesion disrupts maternal behavior in rats: An animal model of schizophrenia.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22283
Abstract: Although individuals with schizophrenia typically present deficits in social interaction, little is known about the quality of their parent-infant interactions. In the present study, we assessed the behavioral effects of neonatal ventral hippocampus lesion (nVHL)… read more here.
Keywords: hippocampus lesion; neonatal ventral; maternal behavior; ventral hippocampus ... See more keywords
Left–right functional asymmetry of ventral hippocampus depends on aversiveness of situations
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.02.028
Abstract: HighlightsThe ventral hippocampus possesses a left–right functional asymmetry in rats.The contribution of each hemisphere depends on the level of aversiveness.Both the left and right VH are activated during weaker anxiety.Only the right VH is activated… read more here.
Keywords: left right; anxiety; functional asymmetry; right functional ... See more keywords
Role of prefrontal cortical 5-HT2A receptors and serotonin transporter in the behavioral deficits in post-pubertal rats following neonatal lesion of the ventral hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112226
Abstract: Neonatal ventral hippocampal-lesioned (NVHL) rats have been shown to display neurochemical and behavioral abnormalities at adulthood, analogous to some of those seen in schizophrenia. Serotonergic neurotransmission is implicated the pathophysiology and treatment of schizophrenia. In… read more here.
Keywords: ht2a; post pubertal; pubertal nvhl; nvhl rats ... See more keywords
Deep Brain Stimulation of the dorsal raphe abolishes serotonin 1A facilitation of AMPA receptor-mediated synaptic currents in the ventral hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113134
Abstract: In a previous study we showed that Deep Brain Stimulation (DBS) of the rat dorsal subregion of the dorsal raphe (DRD), which sends serotonergic projections to forebrain areas, such as the ventral hippocampus, induces anxiolytic-like… read more here.
Keywords: deep brain; stimulation; dorsal; receptor ... See more keywords
The ventral hippocampus CA3 is critical in regulating timing uncertainty in temporal decision-making.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108694
Abstract: Timing uncertainty is a critical component of temporal decision-making, as it determines the decision strategies that maximize reward rate. However, little is known about the biological substrates of timing uncertainty. In this study, we report… read more here.
Keywords: uncertainty; temporal decision; timing uncertainty; decision making ... See more keywords
Ventral hippocampal shock encoding modulates the expression of trace cued fear
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2022.107610
Abstract: The hippocampus is crucial for associative fear learning when the anticipation of threat requires temporal or contextual binding of predictive stimuli as in trace and contextual fear conditioning. Compared with the dorsal hippocampus, far less… read more here.
Keywords: trace; ventral hippocampus; shock; fear ... See more keywords
T180. REDUCED [3H]RO15-4513 RECEPTOR BINDING IN THE VENTRAL HIPPOCAMPUS IN THE MAM DEVELOPMENTAL DISRUPTION MODEL OF SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa029.740
Abstract: Abstract Background Post-mortem studies in schizophrenia patients have repeatedly found abnormalities in the γ-aminobutyric acid (GABA) inhibitory neurotransmission system in the form of parvalbumin (PV)-expressing GABAergic interneuron reduction and aberrant glutamic acid decarboxylase mRNA expression… read more here.
Keywords: schizophrenia; mam; receptor; ventral hippocampus ... See more keywords
Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding
Sign Up to like & getrecommendations! Published in 2019 at "Addiction Biology"
DOI: 10.1111/adb.12624
Abstract: Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned during drug intake can precipitate relapse to drug taking. α7 nicotinic acetylcholine… read more here.
Keywords: hippocampus; morphine; morphine conditioned; reinstatement morphine ... See more keywords
Withdrawal from cocaine conditioning progressively alters AMPA receptor-mediated transmission in the ventral hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Addiction biology"
DOI: 10.1111/adb.13101
Abstract: Drugs of abuse, such as cocaine, produce aberrant changes in synaptic transmission and plasticity that emerge throughout withdrawal. One region of the brain that displays a high degree of synaptic plasticity, as well as connectivity… read more here.
Keywords: transmission; cocaine; withdrawal; ventral hippocampus ... See more keywords
Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12787
Abstract: Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects. Both high levels of folic acid and low levels of folate can be… read more here.
Keywords: folic acid; sst; mthf; ventral hippocampus ... See more keywords
Infusion of C20:0 ceramide into ventral hippocampus triggers anhedonia-like behavior in female and male rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.899627
Abstract: Increased long-chain C20:0 ceramides have been found in the serum of patients with depression. Moreover, ceramides are linked with increased microglia reactivity and inflammatory cytokine production, which are associated with depression. Since ceramides can readily… read more here.
Keywords: anhedonia like; c20 ceramides; like behavior; infusion c20 ... See more keywords