Stimulation of L‐type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.18-0180
Abstract: Making high‐quality dopamine (DA)‐producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assays have low signal‐to‐noise… read more here.
Keywords: type calcium; ventral midbrain; calcium; tyrosine hydroxylase ... See more keywords
Parallel Gene Expression Changes in Ventral Midbrain Dopamine and GABA Neurons during Normal Aging
Sign Up to like & getrecommendations! Published in 2025 at "eNeuro"
DOI: 10.1523/eneuro.0107-25.2025
Abstract: The consequences of aging can vary dramatically between different brain regions and cell types. In the ventral midbrain, dopaminergic neurons develop physiological deficits with normal aging that likely convey susceptibility to neurodegeneration. While nearby GABAergic… read more here.
Keywords: gaba neurons; gene expression; ventral midbrain; dopamine gaba ... See more keywords