Effective derivation of ventricular cardiomyocytes from hPSCs using ascorbic acid-containing maturation medium
Sign Up to like & getrecommendations! Published in 2023 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2023.2189932
Abstract: ABSTRACT Cardiomyocytes derived from human pluripotent stem cells (hPSCs) can be used in various applications including disease modeling, drug safety screening, and novel cell-based cardiac therapies. Here, we report an optimized selection and maturation method… read more here.
Keywords: ascorbic acid; ventricular cardiomyocytes; maturation; selection maturation ... See more keywords
An autofluorescence-based method for the isolation of highly purified ventricular cardiomyocytes
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DOI: 10.1093/cvr/cvx239
Abstract: Aims The aim of our study was to set up a simple and reliable isolation method of living ventricular cardiomyocytes (vCMs) for molecular and biological studies. Methods and results A standard technique for the retrograde… read more here.
Keywords: fitchigh fscdim; highly purified; isolation highly; method isolation ... See more keywords
Calcium current properties in dystrophin‐deficient ventricular cardiomyocytes from aged mdx mice
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13567
Abstract: Duchenne muscular dystrophy (DMD), caused by mutations in the gene encoding for the cytoskeletal protein dystrophin, is linked with severe cardiac complications including cardiomyopathy development and cardiac arrhythmias. We and others recently reported that currents… read more here.
Keywords: mdx mice; ventricular cardiomyocytes; deficient ventricular; aged mdx ... See more keywords
The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15246
Abstract: The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role in the occurrence of arrhythmias, involves cation flux through cation nonselective stretch‐activated channels (SACs). It is well known that nitric oxide (NO)… read more here.
Keywords: ventricular cardiomyocytes; dependent independent; cell; regulation ... See more keywords
Ivabradine acutely improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy
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DOI: 10.14814/phy2.15664
Abstract: The muscular dystrophies caused by dystrophin deficiency, the so‐called dystrophinopathies, are associated with impaired cardiac contractility and arrhythmias, which considerably contribute to disease morbidity and mortality. Impaired Ca handling in ventricular cardiomyocytes has been identified… read more here.
Keywords: ventricular cardiomyocytes; function; ivabradine; dystrophic heart ... See more keywords
Acetylcholine Reduces IKr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020244
Abstract: Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed. However, relatively little… read more here.
Keywords: ventricular cardiomyocytes; effect; action potential; action ... See more keywords
The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158356
Abstract: Leptin is a pleiotropic peptide playing an important role in the regulation of cardiac functions. It is not clear whether leptin directly modulates the mechanical function of atrial cardiomyocytes. We compared the acute effects of… read more here.
Keywords: ventricular cardiomyocytes; rat atrial; effects leptin; acute effects ... See more keywords
Evidence for a Physiological Role of T-Type Ca Channels in Ventricular Cardiomyocytes of Adult Mice
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12060566
Abstract: T-type Ca channels are strongly expressed and important in the developing heart. In the adult heart, these channels play a significant role in pacemaker tissues, but there is uncertainty about their presence and physiological relevance… read more here.
Keywords: ventricular cardiomyocytes; role type; type channels; type ... See more keywords