Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.12.013
Abstract: BACKGROUND Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol may also induce rapid responses via plasma membrane-associated VDR, involving… read more here.
Keywords: ca2 transients; type calcium; mouse ventricular; calcitriol ... See more keywords
Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.01.013
Abstract: Acute inflammation often contributes to the increased arrhythmogenesis in the cardiomyocytes. We investigated the protective effects of pravastatin on calcium disorders induced by acute administration of pro-inflammatory cytokines in isolated ventricular myocytes and its underlying… read more here.
Keywords: ros pathway; mitochondrial ros; ventricular myocytes; ca2 ... See more keywords
Lentiviral transduction of neonatal rat ventricular myocytes preserves ultrastructural features of genetically modified cells.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.07.015
Abstract: Preserving morphological features that are important for cell function and structure is a critical parameter for in vitro experiments with rat cardiomyocytes. Lentiviral vectors are commonly used as gene transfer tool because of its high… read more here.
Keywords: features genetically; rat ventricular; ventricular myocytes; neonatal rat ... See more keywords
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.01.008
Abstract: Transient receptor potential canonical 1 (TRPC1) protein is abundantly expressed in cardiomyocytes. While TRPC1 is supposed to be critically involved in cardiac hypertrophy, its physiological role in cardiomyocytes is poorly understood. We investigated the subcellular… read more here.
Keywords: location; microscopy; trpc1; ventricular myocytes ... See more keywords
Structural variability of dyads relates to calcium release in rat ventricular myocytes
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DOI: 10.1038/s41598-020-64840-5
Abstract: Cardiac excitation-contraction coupling relies on dyads, the intracellular calcium synapses of cardiac myocytes, where the plasma membrane contacts sarcoplasmic reticulum and where electrical excitation triggers calcium release. The morphology of dyads and dynamics of local… read more here.
Keywords: structural variability; calcium release; release sites; ventricular myocytes ... See more keywords
Bifurcations Caused by Feedback between Voltage and Intracellular Ion Concentrations in Ventricular Myocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Physical review letters"
DOI: 10.1103/physrevlett.123.218101
Abstract: We develop an iterated map model to describe the bifurcations and complex dynamics caused by the feedback between voltage and intracellular Ca^{2+} and Na^{+} concentrations in paced ventricular myocytes. Voltage and Ca^{2+} can form either… read more here.
Keywords: voltage; feedback voltage; caused feedback; ventricular myocytes ... See more keywords
Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation.
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.120.046450
Abstract: Background: Calmodulin mutations are associated with arrhythmia syndromes in humans. Exome sequencing previously identified a de novo mutation in CALM1 resulting in a p.N98S substitution in a patient with sinus bradycardia and stress-induced bidirectional ventricular… read more here.
Keywords: calm1n98s; arrhythmia; mice; ventricular myocytes ... See more keywords
Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes
Sign Up to like & getrecommendations! Published in 2019 at "BioMedical Engineering OnLine"
DOI: 10.1186/s12938-019-0690-x
Abstract: PurposeAlthough the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle… read more here.
Keywords: model human; ventricular myocytes; tension; human ventricular ... See more keywords
Kv4.3 expression reverses ICa remodeling in ventricular myocytes of heart failure
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DOI: 10.18632/oncotarget.21956
Abstract: Background Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent L-type calcium channel (LTCC) current (ICa) remodeling is an important contributor to the disruption of calcium homeostasis in heart failure (HF). We have reported that Kv4.3 proteins play an… read more here.
Keywords: heart failure; expression; ventricular myocytes; ica remodeling ... See more keywords
Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1155601
Abstract: Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial. In studies on myocytes from CPVT mice, inhibition of proarrhythmic… read more here.
Keywords: inhibition; ventricular myocytes; cells flecainide; action ... See more keywords
Cholesterol Protects Against Acute Stress-Induced T-Tubule Remodeling in Mouse Ventricular Myocytes
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01516
Abstract: Efficient excitation-contraction coupling in ventricular myocytes depends critically on the presence of the t-tubular network. It has been recently demonstrated that cholesterol, a major component of the lipid bilayer, plays an important role in long-term… read more here.
Keywords: tubule remodeling; cholesterol; stress; ventricular myocytes ... See more keywords