Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2016.12.013
Abstract: BACKGROUND Calcitriol, the bioactive metabolite of vitamin D, exerts its effects through interaction with the nuclear vitamin D receptor (VDR) to induce genomic responses. Calcitriol may also induce rapid responses via plasma membrane-associated VDR, involving… read more here.
Keywords: ca2 transients; type calcium; mouse ventricular; calcitriol ... See more keywords
Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.01.013
Abstract: Acute inflammation often contributes to the increased arrhythmogenesis in the cardiomyocytes. We investigated the protective effects of pravastatin on calcium disorders induced by acute administration of pro-inflammatory cytokines in isolated ventricular myocytes and its underlying… read more here.
Keywords: ros pathway; mitochondrial ros; ventricular myocytes; ca2 ... See more keywords
Lentiviral transduction of neonatal rat ventricular myocytes preserves ultrastructural features of genetically modified cells.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.07.015
Abstract: Preserving morphological features that are important for cell function and structure is a critical parameter for in vitro experiments with rat cardiomyocytes. Lentiviral vectors are commonly used as gene transfer tool because of its high… read more here.
Keywords: features genetically; rat ventricular; ventricular myocytes; neonatal rat ... See more keywords
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.01.008
Abstract: Transient receptor potential canonical 1 (TRPC1) protein is abundantly expressed in cardiomyocytes. While TRPC1 is supposed to be critically involved in cardiac hypertrophy, its physiological role in cardiomyocytes is poorly understood. We investigated the subcellular… read more here.
Keywords: location; microscopy; trpc1; ventricular myocytes ... See more keywords
Structural variability of dyads relates to calcium release in rat ventricular myocytes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64840-5
Abstract: Cardiac excitation-contraction coupling relies on dyads, the intracellular calcium synapses of cardiac myocytes, where the plasma membrane contacts sarcoplasmic reticulum and where electrical excitation triggers calcium release. The morphology of dyads and dynamics of local… read more here.
Keywords: structural variability; calcium release; release sites; ventricular myocytes ... See more keywords
Bifurcations Caused by Feedback between Voltage and Intracellular Ion Concentrations in Ventricular Myocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Physical review letters"
DOI: 10.1103/physrevlett.123.218101
Abstract: We develop an iterated map model to describe the bifurcations and complex dynamics caused by the feedback between voltage and intracellular Ca^{2+} and Na^{+} concentrations in paced ventricular myocytes. Voltage and Ca^{2+} can form either… read more here.
Keywords: voltage; feedback voltage; caused feedback; ventricular myocytes ... See more keywords
Pericytes in cardiac Electro-Metabolic Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1434
Abstract: Blood flow in the heart is preferentially directed to regions of high metabolic activity while bypassing less active areas with lower demands. This regulation is believed to be highly localized and finely controlled, mediated by… read more here.
Keywords: physiology; heart; ventricular myocytes; metabolic signaling ... See more keywords
Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation.
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.120.046450
Abstract: Background: Calmodulin mutations are associated with arrhythmia syndromes in humans. Exome sequencing previously identified a de novo mutation in CALM1 resulting in a p.N98S substitution in a patient with sinus bradycardia and stress-induced bidirectional ventricular… read more here.
Keywords: calm1n98s; arrhythmia; mice; ventricular myocytes ... See more keywords
Abstract Thu099: Single-Cell RNA-seq Analysis Reveals a Two-Step Mechanism for TBX18-Mediated Reprogramming of Ventricular Myocytes into Pacemaker Cells
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu099
Abstract: Introduction: TBX18-mediated reprogramming converts ventricular myocytes (VMs) into pacemaker-like cells (iPMs), creating de novo pacing in vitro and in vivo. Here, we employ single-cell RNA sequencing (scRNA-seq) and ATAC-seq to elucidate the molecular mechanisms underlying… read more here.
Keywords: pacemaker; ventricular myocytes; cell; seq ... See more keywords
Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes
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DOI: 10.1186/s12938-019-0690-x
Abstract: PurposeAlthough the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle… read more here.
Keywords: model human; ventricular myocytes; tension; human ventricular ... See more keywords
The air pollutant phenanthrene disrupts calcium cycling and alters repolarization in female sheep ventricular cardiomyocytes
Sign Up to like & getrecommendations! Published in 2025 at "Physiological Reports"
DOI: 10.14814/phy2.70471
Abstract: Multiple epidemiological studies link cardiac dysfunction with increased levels of air pollution. While cellular mechanisms underlying such dysfunction are yet to be fully elucidated, a proposed mediator of this effect is phenanthrene, a 3‐ringed polycyclic… read more here.
Keywords: phenanthrene; calcium transient; air pollutant; ventricular myocytes ... See more keywords