SENP1‐Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202400741
Abstract: Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin‐specific protease 1 (SENP1) is downregulated in post‐MI mice and in patients with severe heart… read more here.
Keywords: fibrosis; hsp90ab1 desumoylation; senp1 mediated; mediated hsp90ab1 ... See more keywords
Cardiac resynchronization therapy improves left ventricular remodeling and function compared with right ventricular pacing in patients with atrioventricular block
Sign Up to like & getrecommendations! Published in 2018 at "Heart Failure Reviews"
DOI: 10.1007/s10741-018-9722-z
Abstract: Right ventricular pacing (RVP) exerts a detrimental effect on left ventricular (LV) remodeling. In patients with atrioventricular block (AVB) that require ventricular pacing, the effect of biventricular pacing (BiVP) versus RVP on LV remodeling and… read more here.
Keywords: remodeling function; right ventricular; ventricular pacing; ventricular remodeling ... See more keywords
Determination of microRNAs associated with adverse left ventricular remodeling after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04330-y
Abstract: Increasing evidence indicates that microRNA (miRNA) regulated mechanisms in myocardial healing and ventricular remodeling following acute myocardial infarction (AMI). We aim to comprehensively investigate changes of exosomal miRNA profile during the post-MI period and determine… read more here.
Keywords: left ventricular; associated adverse; mir; myocardial infarction ... See more keywords
Paeoniflorin attenuates cuproptosis and ameliorates left ventricular remodeling after AMI in hypobaric hypoxia environments
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-024-01781-7
Abstract: This study investigates the cardioprotective effects of Paeoniflorin (PF) on left ventricular remodeling following acute myocardial infarction (AMI) under conditions of hypobaric hypoxia. Left ventricular remodeling post-AMI plays a pivotal role in exacerbating heart failure,… read more here.
Keywords: remodeling ami; left ventricular; hypobaric hypoxia; ventricular remodeling ... See more keywords
Insights of Chinese medicine on ventricular remodeling: Multiple-targets, individualized-treatment
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-017-2415-y
Abstract: Ventricular remodeling (VR) can be induced by myocardial injury, leading to progressive cardiac dysfunction and heart failure, and is associated with high morbidity and mortality. Despite being studied for more than 3 decades, current therapeutic… read more here.
Keywords: medicine; insights chinese; medicine ventricular; chinese medicine ... See more keywords
ST2 as a predictor of late ventricular remodeling after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.02.058
Abstract: Out of 163 STEMI patients, 33 presented left ventricular remodeling (LVR) as assessed by multiple cardiac magnetic resonance (CMR) scans. LVR patients were identified as EarlyLVR (LVR occurring between baseline and 3 months) or LateLVR (LVR… read more here.
Keywords: probnp sws; st2 predictor; st2 probnp; patients presented ... See more keywords
microRNA-30e up-regulation alleviates myocardial ischemia-reperfusion injury and promotes ventricular remodeling via SOX9 repression.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.11.009
Abstract: AIM At present, studies have focused on microRNAs (miRNAs) in myocardial ischemia-reperfusion injury (MI/RI). But the specific role of miR-30e hasn't been fully explored. Thus, this study is to uncover the mechanism of miR-30e in… read more here.
Keywords: 30e regulation; mir 30e; sox9; ventricular remodeling ... See more keywords
Osteoblast MR deficiency protects against adverse ventricular remodeling after myocardial infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2022.03.003
Abstract: RATIONALE Mineralocorticoid receptor (MR) antagonists have been clinically used to treat heart failure. However, the underlying cellular and molecular mechanisms remain incompletely understood. METHODS AND RESULTS Using osteoblast MR knockout (MRobko) mouse in combination with… read more here.
Keywords: ventricular remodeling; deficiency; myocardial infarction; osteoblast deficiency ... See more keywords
RATIONALE AND METHODS OF THE PROSPECTIVE STUDY OF BIOMARKERS, SYMPTOM IMPROVEMENT AND VENTRICULAR REMODELING DURING ENTRESTO THERAPY FOR HEART FAILURE (PROVE-HF) STUDY
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)34100-1
Abstract: Background: Therapy with sacubitril/valsartan improves outcome in those with heart failure with reduced ejection fraction (HFrEF). Questions remain regarding effect of sacubitril/valsartan on left ventricular (LV) remodeling as well as its effects on circulating biomarkers… read more here.
Keywords: ventricular remodeling; therapy; study; heart failure ... See more keywords
REVERSE VENTRICULAR REMODELING IN PATIENTS WITH VALVULAR HEART DISEASE UNDERGOING CARDIAC RESYNCHRONIZATION THERAPY
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)31026-5
Abstract: Patients with non-ischemic cardiomyopathy are largely regarded to derive superior response to cardiac resynchronization therapy (CRT)compared to ischemic patients. Patients with non-ischemic cardiomyopathy (NICM), however, are heterogeneous with multiple different myocardial substrates. We sought to read more here.
Keywords: resynchronization therapy; cardiac resynchronization; ventricular remodeling; reverse ventricular ... See more keywords
Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33491-y
Abstract: Reliable noninvasive prognostic biomarkers for left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) are needed. This study aimed to evaluate a panel of circulating microRNAs (miRNAs) as biomarkers of LV remodeling using cardiovascular… read more here.
Keywords: mir 1254; segment elevation; mir; myocardial infarction ... See more keywords