Association of Generalized Anxiety Disorder With Autonomic Hypersensitivity and Blunted Ventromedial Prefrontal Cortex Activity During Peripheral Adrenergic Stimulation
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2021.4225
Abstract: Key Points Question Do individuals with generalized anxiety disorder (GAD) show abnormal physiological, perceptual, or neural responses during peripheral β-adrenergic stimulation that may indicate interoceptive dysfunction? Findings In this crossover randomized clinical trial, female patients… read more here.
Keywords: ventromedial prefrontal; adrenergic stimulation; generalized anxiety; prefrontal cortex ... See more keywords
The Multifaceted Role of the Ventromedial Prefrontal Cortex in Emotion, Decision Making, Social Cognition, and Psychopathology
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.10.030
Abstract: The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social, cognitive, and affective functions that are commonly disrupted in mental illness. In this review, we summarize data from a diverse array of… read more here.
Keywords: emotion; cortex; ventromedial prefrontal; decision making ... See more keywords
Investigating the role of CB1 endocannabinoid transmission in the anti-fear and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.01.029
Abstract: Deep brain stimulation (DBS) delivered to the ventromedial prefrontal cortex (vmPFC) of rats induces anti-fear and anxiolytic-like behaviours, while reducing principal cell firing in the basolateral amygdala (BLA). In parallel, the endocannabinoid system, particularly in… read more here.
Keywords: anti fear; deep brain; ventromedial prefrontal; fear anxiolytic ... See more keywords
Ventromedial Prefrontal Cortex Encodes a Latent Estimate of Cumulative Reward
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.12.038
Abstract: Humans and other animals accumulate resources, or wealth, by making successive risky decisions. If and how risk attitudes vary with wealth remains an open question. Here humans accumulated reward by accepting or rejecting successive monetary gambles… read more here.
Keywords: cortex encodes; ventromedial prefrontal; encodes latent; reward ... See more keywords
The ventromedial prefrontal cortex is particularly responsive to social evaluations requiring the use of person-knowledge
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41544-z
Abstract: Humans can rely on diverse sources of information to evaluate others, including knowledge (e.g., occupation, likes and dislikes, education, etc.) and perceptual cues (e.g., attractiveness, race, etc.). Previous research has identified brain regions supporting person… read more here.
Keywords: person knowledge; availability person; ventromedial prefrontal; person ... See more keywords
Primate Ventromedial Prefrontal Cortex Neurons Continuously Encode the Willingness to Engage in Reward-Directed Behavior
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw351
Abstract: To survive in their complex environment, primates must integrate information over time and adjust their actions beyond immediate events. The underlying neurobiological processes, however, remain unclear. Here, we assessed the contribution of the ventromedial prefrontal… read more here.
Keywords: information; neurons continuously; cortex; ventromedial prefrontal ... See more keywords
Perspective-taking is associated with increased discriminability of affective states in the ventromedial prefrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Social Cognitive and Affective Neuroscience"
DOI: 10.1093/scan/nsac035
Abstract: Abstract Recent work using multivariate-pattern analysis (MVPA) on functional magnetic resonance imaging (fMRI) data has found that distinct affective states produce correspondingly distinct patterns of neural activity in the cerebral cortex. However, it is unclear… read more here.
Keywords: perspective taking; affective states; classification; ventromedial prefrontal ... See more keywords
Attention to the other’s body sensations modulates the ventromedial prefrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Social Cognitive and Affective Neuroscience"
DOI: 10.1093/scan/nsac043
Abstract: Abstract Theory of Mind (ToM) is involved in experiencing the mental states and/or emotions of others. A further distinction can be drawn between emotion and perception/sensation. We investigated the mechanisms engaged when participants’ attention is… read more here.
Keywords: attention body; ventromedial prefrontal; prefrontal cortex; cortex ... See more keywords
Repeated ketamine administration induces recognition memory impairment together with morphological changes in neurons from ventromedial prefrontal cortex, dorsal striatum, and hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000571
Abstract: Ketamine is an anesthetic agent that antagonizes N-methyl-d-aspartate receptors, inducing psychotic-like symptoms in healthy humans and animals. This agent has been used as a pharmacological tool for studying biochemical and physiological mechanisms underlying the clinical… read more here.
Keywords: prefrontal cortex; memory impairment; recognition memory; ventromedial prefrontal ... See more keywords
Endogenous variation in ventromedial prefrontal cortex state dynamics during naturalistic viewing reflects affective experience
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf7129
Abstract: The vmPFC ascribes affective meaning to experiences as they unfold and exhibits unique idiographic spatiotemporal dynamics. How we process ongoing experiences is shaped by our personal history, current needs, and future goals. Consequently, ventromedial prefrontal… read more here.
Keywords: state; vmpfc; ventromedial prefrontal; ongoing experiences ... See more keywords
Electroacupuncture Attenuates Anxiety-Like Behaviors in a Rat Model of Post-traumatic Stress Disorder: The Role of the Ventromedial Prefrontal Cortex
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.690159
Abstract: Electroacupuncture (EA) is a promising clinical approach to treating posttraumatic stress disorder (PTSD), yet the mechanisms whereby EA can alleviate anxiety and other PTSD symptoms have yet to be clarified. In the present report, rats… read more here.
Keywords: stress disorder; ventromedial prefrontal; anxiety like; model ... See more keywords