Verapamil attenuates scopolamine induced cognitive deficits by averting oxidative stress and mitochondrial injury – A potential therapeutic agent for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00498-x
Abstract: Alzheimer’s disease (AD) is a multifactorial disorder where amyloid beta (Aβ) plaques, Ca 2+ dysregulation, excessive oxidative stress, mitochondrial dysfunction and synaptic loss operate synergistically to bring about cholinergic deficits and dementia. New therapeutic interventions… read more here.
Keywords: alzheimer disease; stress mitochondrial; verapamil; oxidative stress ... See more keywords
Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2276-2
Abstract: PurposeOxidative stress is a hallmark of Alzheimer’s Disease (AD) and promotes tau phosphorylation. Since Thioredoxin Interacting protein (TXNIP), the inhibitor of the anti-oxidant system of Thioredoxin, is up regulated in the hippocampus of AD patients,… read more here.
Keywords: p38 mapk; ser202 thr205; verapamil; tau phosphorylation ... See more keywords
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.090
Abstract: The objective of this study was to investigate the exact therapeutic effects of Verapamil on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the molecular mechanism involved, through using LPS-induced animal models as well as LPS-stimulated… read more here.
Keywords: lps induced; therapeutic effect; verapamil; injury ... See more keywords
How CaV1.2-bound verapamil blocks Ca2+ influx into cardiomyocyte: Atomic level views.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2018.11.017
Abstract: The first clinically used antiarrhythmic, antianginal and anti-hypertensive phenylalkylamine, verapamil's cardiovascular activity is inextricably linked to its ability to antagonize Ca2+ overload via blocking CaV1.2, a cardiac L-type Ca2+ channel of undisputed physiological and pharmacological… read more here.
Keywords: verapamil blocks; cav1 bound; atomic level; verapamil ... See more keywords
Topical Administration of Verapamil in Poly(ethylene glycol)-Modified Liposomes for Enhanced Sinonasal Tissue Residence in Chronic Rhinosinusitis: Ex Vivo and In Vivo Evaluations.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00943
Abstract: Verapamil is a calcium channel blocker that holds promise for the therapy of chronic rhinosinusitis (CRS) with and without nasal polyps. The verapamil-induced side effects limit its tolerated dose via the oral route, underscoring the… read more here.
Keywords: verapamil; vivo; administration; poly ethylene ... See more keywords
Solanaceae glycoalkaloids: α-solanine and α-chaconine modify the cardioinhibitory activity of verapamil
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2094966
Abstract: Abstract Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity. Objective This study investigated the potential interaction between verapamil and glycoalkaloids. Material and methods The cardioactivity of verapamil and glycoalkaloids (α-solanine and α-chaconine) was tested in adult… read more here.
Keywords: verapamil; solanaceae glycoalkaloids; verapamil glycoalkaloids; activity ... See more keywords
Protective effect of cilostazol and verapamil against thioacetamide-induced hepatotoxicity in rats may involve Nrf2/GSK-3β/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology research"
DOI: 10.1093/toxres/tfac045
Abstract: Background Verapamil (VER) and cilostazol (Cilo) are mostly used as cardiovascular drugs; they have beneficial effects on different organs toxicities. Aim we investigated whether the Nuclear factor erythroid 2-related factor 2 (Nrf2), Glycogen synthase kinase-3β… read more here.
Keywords: verapamil; cilostazol; hepatotoxicity; taa ... See more keywords
Comparison of BQ123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000002021
Abstract: Background The optimal vasodilator to avoid hepatic artery vasospasm during normothermic ex vivo liver perfusion (NEVLP) is yet to be determined. We compared safety and efficacy of BQ123 (endothelin1 antagonist), epoprostenol (prostacyclin analogue), and verapamil… read more here.
Keywords: bq123; epoprostenol; perfusion; group ... See more keywords
Intraoperative Verapamil Fails to Reduce Delayed Graft Function in Donation After Circulatory Death Renal Allografts
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000001250
Abstract: Background. The shortage of transplantable organs has led to increased utilization of kidneys that may be particularly vulnerable to ischemia-reperfusion injury (IRI) and delayed graft function (DGF). Kidneys from donation after circulatory death (DCD) donors… read more here.
Keywords: verapamil; graft function; dcd; delayed graft ... See more keywords
Pharmacokinetic interaction between verapamil and ritonavir-boosted nirmatrelvir: implications for the management of COVID-19 in patients with hypertension
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Case Reports"
DOI: 10.1136/bcr-2022-252677
Abstract: A woman in her 80s was brought to the emergency department for acute onset of generalised weakness, lethargy and altered mental state. The emergency medical service found her to have symptomatic bradycardia, and transcutaneous pacing… read more here.
Keywords: verapamil; interaction; hypertension; boosted nirmatrelvir ... See more keywords
Morphological changes of intracranial pressure quantifies vasodilatory effect of verapamil to treat cerebral vasospasm
Sign Up to like & getrecommendations! Published in 2020 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/neurintsurg-2019-015499
Abstract: Introduction After aneurysmal subarachnoid hemorrhage (SAH), both proximal and distal cerebral vasospasm can contribute to the development of delayed cerebral ischemia. Intra-arterial (IA) vasodilators are a mainstay of treatment for distal arterial vasospasm, but no… read more here.
Keywords: vasospasm; cerebral vasospasm; morphological changes; intracranial pressure ... See more keywords